Assay Detail
Binding
CHEMBL3772142
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Inhibition of human AChE using acetylthiocholine iodide as substrate preincubated for 5 mins followed by substrate addition measured after 60 to 300 sec by Ellman's method
32
Total Activities
32
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Tricyclic phenothiazine and phenoselenazine derivatives as potential multi-targeting agents to treat Alzheimer's disease
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 32 | 5.33 | 7.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL502 | DONEPEZIL | 4.0 | 1 | 7.40 |
| CHEMBL95 | TACRINE | 4.0 | 1 | 6.80 |
| CHEMBL659 | GALANTAMINE | 4.0 | 1 | 5.58 |
| CHEMBL3770206 | — | — | 1 | 5.34 |
| CHEMBL3769576 | — | — | 1 | 5.34 |
| CHEMBL3770978 | — | — | 1 | 5.29 |
| CHEMBL3770569 | — | — | 1 | 5.27 |
| CHEMBL3769834 | — | — | 1 | 5.25 |
| CHEMBL3770203 | — | — | 1 | 5.24 |
| CHEMBL3770356 | — | — | 1 | 5.24 |
| CHEMBL3769537 | — | — | 1 | 5.23 |
| CHEMBL1801816 | — | — | 1 | 5.23 |
| CHEMBL3770479 | — | — | 1 | 5.22 |
| CHEMBL51085 | EBSELEN | 3.0 | 1 | 5.21 |
| CHEMBL3769555 | — | — | 1 | 5.21 |
| CHEMBL1327885 | — | — | 1 | 5.21 |
| CHEMBL3769833 | — | — | 1 | 5.21 |
| CHEMBL3770577 | — | — | 1 | 5.20 |
| CHEMBL3769862 | — | — | 1 | 5.20 |
| CHEMBL239618 | — | — | 1 | 5.20 |
| CHEMBL3770803 | — | — | 1 | 5.19 |
| CHEMBL3770071 | — | — | 1 | 5.19 |
| CHEMBL3769811 | — | — | 1 | 5.19 |
| CHEMBL3771233 | — | — | 1 | 5.17 |
| CHEMBL240047 | — | — | 1 | 5.15 |
| CHEMBL828 | PHENOTHIAZINE | 2.0 | 1 | 5.14 |
| CHEMBL1411769 | — | — | 1 | 5.13 |
| CHEMBL394753 | — | — | 1 | 5.13 |
| CHEMBL3770516 | — | — | 1 | 5.12 |
| CHEMBL3770866 | — | — | 1 | 5.10 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL502 | DONEPEZIL | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL95 | TACRINE | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL659 | GALANTAMINE | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL3770206 | — | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL3769576 | — | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL3770978 | — | IC50 | = | 5100.0 | nM | 5.29 |
| CHEMBL3770569 | — | IC50 | = | 5400.0 | nM | 5.27 |
| CHEMBL3769834 | — | IC50 | = | 5600.0 | nM | 5.25 |
| CHEMBL3770203 | — | IC50 | = | 5800.0 | nM | 5.24 |
| CHEMBL3770356 | — | IC50 | = | 5800.0 | nM | 5.24 |
| CHEMBL3769537 | — | IC50 | = | 5900.0 | nM | 5.23 |
| CHEMBL1801816 | — | IC50 | = | 5900.0 | nM | 5.23 |
| CHEMBL3770479 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL3769555 | — | IC50 | = | 6200.0 | nM | 5.21 |
| CHEMBL51085 | EBSELEN | IC50 | = | 6200.0 | nM | 5.21 |
| CHEMBL3769833 | — | IC50 | = | 6200.0 | nM | 5.21 |
| CHEMBL1327885 | — | IC50 | = | 6200.0 | nM | 5.21 |
| CHEMBL3770577 | — | IC50 | = | 6300.0 | nM | 5.20 |
| CHEMBL3769862 | — | IC50 | = | 6300.0 | nM | 5.20 |
| CHEMBL239618 | — | IC50 | = | 6300.0 | nM | 5.20 |
| CHEMBL3770803 | — | IC50 | = | 6500.0 | nM | 5.19 |
| CHEMBL3770071 | — | IC50 | = | 6400.0 | nM | 5.19 |
| CHEMBL3769811 | — | IC50 | = | 6400.0 | nM | 5.19 |
| CHEMBL3771233 | — | IC50 | = | 6700.0 | nM | 5.17 |
| CHEMBL240047 | — | IC50 | = | 7100.0 | nM | 5.15 |
| CHEMBL828 | PHENOTHIAZINE | IC50 | = | 7300.0 | nM | 5.14 |
| CHEMBL1411769 | — | IC50 | = | 7400.0 | nM | 5.13 |
| CHEMBL394753 | — | IC50 | = | 7400.0 | nM | 5.13 |
| CHEMBL3770516 | — | IC50 | = | 7500.0 | nM | 5.12 |
| CHEMBL3770866 | — | IC50 | = | 7900.0 | nM | 5.10 |
| CHEMBL239400 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL1801815 | — | IC50 | = | 9900.0 | nM | 5.00 |