Alpha-synuclein · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-14Alpha-synuclein shows clinical signal disease relevance led by Parkinson disease. 2 linked drugs keep the current disease frame grounded. Protein identity stays anchored to UniProt P37840. Start with Parkinson disease, then reuse UniProt P37840 as the stable protein anchor across project notes and exports.
Start with Parkinson disease, then reuse UniProt P37840 as the stable protein anchor across project notes and exports.
Alpha-synuclein shows clinical signal disease relevance led by Parkinson disease. 2 linked drugs remain visible in the same block.
Start review with Parkinson disease because it currently carries clinical signal support. Linked drugs include CINPANEMAB, PRASINEZUMAB. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
Disease source · ChEMBL drug mechanism + indication proxyAlpha-synuclein
Review this target as Alpha-synuclein, mapped to UniProt P37840. Sequence length is 140 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Alpha-synuclein as ChEMBL target CHEMBL6152, mapped to UniProt P37840. Disease framing currently uses the Open Targets-ready proxy contract.
Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.
Choose the first block or source based on the question you are trying to answer.
Start here when your first question is whether Alpha-synuclein is the right protein anchor across sources, using UniProt P37840 as the stable mapping.
Jump to Protein ContextUse this block first when you need to confirm why Parkinson disease is currently framed as clinical signal support. It currently carries 2 linked drugs in the same disease frame.
Jump to Disease ContextOpen the one-page evidence card when you want the rationale, activity base, and attribution together.
Open Review-ready CardVerify identity, organism, and the fastest next research jumps from the same page.
| Preferred Name | Alpha-synuclein |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | P37840 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Alpha-synuclein |
| UniProt Accession | P37840 |
| Component Type | Protein |
| Sequence Length | 140 aa |
Alpha-synuclein
Review this target as Alpha-synuclein, mapped to UniProt P37840. Sequence length is 140 aa.
Open Targets-ready disease context using the current target-indication evidence contract.
Alpha-synuclein shows clinical signal disease relevance led by Parkinson disease.
Start review with Parkinson disease because it currently carries clinical signal support. Linked drugs include CINPANEMAB, PRASINEZUMAB. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL5896450 | 9.31 | Kd | 0.49 | Preclinical |
| CHEMBL5771524 | 9.28 | Kd | 0.53 | Preclinical |
| CHEMBL5790440 | 9.14 | Kd | 0.73 | Preclinical |
| CHEMBL5843241 | 9.1 | Kd | 0.79 | Preclinical |
| CHEMBL5843281 | 9.0 | Kd | 1.0 | Preclinical |
| CHEMBL4637732 | 8.99 | Kd | 1.03 | Preclinical |
| CHEMBL5286894 | 8.93 | IC50 | 1.18 | Preclinical |
| CHEMBL5759738 | 8.9 | Kd | 1.27 | Preclinical |
| CHEMBL6035240 | 8.85 | Kd | 1.4 | Preclinical |
| CHEMBL3593932 | 8.68 | Ki | 2.1 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 254 | 328 | 6.5 |
| cell-based format | 88 | 51 | 5.5 |
| assay format | 67 | 75 | 6.6 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 1 | 0 | — |