Skip to main content
Free research Free research Free compound review with research home and workspace preview
Quick search ChEMBL 36
Compound Detail

CHEMBL1908919

FLORBETAPIR
💊 Approved Drug
Enter ChEMBL ID:
Free Research Context This compound will appear in recent viewed items on the research home for this browser.
Research home View demo workspace
💊 Approved Drug
CNc1ccc(/C=C/c2ccc(OCCOCCOCCF)nc2)cc1
ChEMBL ↗ Properties Compare Identifier

Basic Information

ChEMBL ID CHEMBL1908919
Name FLORBETAPIR
Phase Approved
Structure Type MOL
InChI Key YNDIAUKFXKEXSV-NSCUHMNNSA-N

Known Names

Av-45 Florbetapir
4
Targets
9
Activities
2
Assay Types
0
PK Parameters
3
Publications
2
Known Names

Molecular Properties

360.4
MW (Da)
3.68
ALogP
5
HBA
1
HBD
52.6
PSA (Ų)
0.59
QED
0
Ro5 Violations
12
Rot. Bonds

Drug Information

Molecule Type Small molecule
First Approval 2012
Availability Prescription
Chirality Achiral

Routes of Administration

Parenteral

Flags

First in Class
USAN Year 2009

Extended Properties

Molecular Formula C20H25FN2O3
MW 360.43
Aromatic Rings 2
Heavy Atoms 26
NP-Likeness -0.94

Activity Summary

Ki 5 meas. best 8.66
Kd 4 meas. best 8.78

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Unchecked
CHEMBL612545
 Kd 8.78 8.78 1.7 1
Unchecked
CHEMBL612545
 Ki 8.66 8.66 2.2 1
Amyloid-beta precursor protein
CHEMBL2487
 Ki 7.94 7.915 11.4 2
Microtubule-associated protein tau
CHEMBL1293224
 Kd 7.71 7.71 19.6 1
Alpha-synuclein
CHEMBL6152
 Kd 7.61 7.61 24.3 2
Microtubule-associated protein tau
CHEMBL1293224
 Ki 7.51 7.51 30.6 1
Alpha-synuclein
CHEMBL6152
 Ki 7.12 7.12 76.6 1

Activity Data Samples

Top measurements by pChEMBL value

Target Type Rel. Value Units pChEMBL Assay PubMed
Unchecked Kd = 1.68 nM 8.78 In Vitro Direct Determination By Fluorescence: Table 6 & 7: Fresh solutions of e... -
Unchecked Ki = 2.2 nM 8.66 In Vitro Inhibition Assay: Table 5: Fresh solutions of the test compounds (2.5 m... -
Amyloid-beta precursor protein Ki = 11.4 nM 7.94 Displacement of [125I]BOB-4 from Amyloid beta (1 to 42) (unknown origin) 26435514
Amyloid-beta precursor protein Ki = 12.8 nM 7.89 Displacement of [125I]IMPY from amyloid beta (1 to 42) (unknown origin) after 3 ... 24900717
Microtubule-associated protein tau Kd = 19.6 nM 7.71 In Vitro Direct Determination By Fluorescence: Table 6 & 7: Fresh solutions of e... -
Alpha-synuclein Kd = 24.3 nM 7.61 In Vitro Direct Determination By Fluorescence: Table 6 & 7: Fresh solutions of e... -
Alpha-synuclein Kd = 24.3 nM 7.61 In Vitro Direct Determination By Fluorescence: Table 6 & 7: Fresh solutions of e... -
Microtubule-associated protein tau Ki = 30.6 nM 7.51 In Vitro Inhibition Assay: Table 5: Fresh solutions of the test compounds (2.5 m... -
Alpha-synuclein Ki = 76.6 nM 7.12 In Vitro Inhibition Assay: Table 5: Fresh solutions of the test compounds (2.5 m... -

Literature References

PubMed DOI Target Context # Activities
26435514 10.1016/j.ejmech.2015.09.028 Amyloid-beta precursor protein 2
- 10.6019/CHEMBL4651402 SARS-CoV-2 2
24900717 10.1021/ml4000707 Amyloid-beta precursor protein 1

Data from ChEMBL 36 via Core Engine