Amyloid-beta precursor protein · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-12Amyloid-beta precursor protein shows approved-linked disease relevance led by Alzheimer disease. 4 more disease programs remain visible in the same review block. 13 linked drugs keep the current disease frame grounded. Protein identity stays anchored to UniProt P05067. Start with Alzheimer disease, then reuse UniProt P05067 as the stable protein anchor across project notes and exports.
Start with Alzheimer disease, then reuse UniProt P05067 as the stable protein anchor across project notes and exports.
Amyloid-beta precursor protein shows approved-linked disease relevance led by Alzheimer disease. 4 more disease programs remain visible in the same review block. 13 linked drugs remain visible in the same block.
Start review with Alzheimer disease because it currently carries approved-linked support. Linked drugs include ADUCANUMAB, AMILOMOTIDE, BAPINEUZUMAB, CRENEZUMAB. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
Disease source · ChEMBL drug mechanism + indication proxyAmyloid-beta precursor protein
Review this target as Amyloid-beta precursor protein, mapped to UniProt P05067. Sequence length is 770 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Amyloid-beta precursor protein as ChEMBL target CHEMBL2487, mapped to UniProt P05067. Disease framing currently uses the Open Targets-ready proxy contract.
Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.
Choose the first block or source based on the question you are trying to answer.
Start here when your first question is whether Amyloid-beta precursor protein is the right protein anchor across sources, using UniProt P05067 as the stable mapping.
Jump to Protein ContextUse this block first when you need to confirm why Alzheimer disease is currently framed as approved-linked support. It currently carries 13 linked drugs in the same disease frame.
Jump to Disease ContextOpen the one-page evidence card when you want the rationale, activity base, and attribution together.
Open Review-ready CardVerify identity, organism, and the fastest next research jumps from the same page.
| Preferred Name | Amyloid-beta precursor protein |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | P05067 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Amyloid-beta precursor protein |
| UniProt Accession | P05067 |
| Component Type | Protein |
| Sequence Length | 770 aa |
Amyloid-beta precursor protein
Review this target as Amyloid-beta precursor protein, mapped to UniProt P05067. Sequence length is 770 aa.
Open Targets-ready disease context using the current target-indication evidence contract.
Amyloid-beta precursor protein shows approved-linked disease relevance led by Alzheimer disease. 4 more disease programs remain visible in the same review block.
Start review with Alzheimer disease because it currently carries approved-linked support. Linked drugs include ADUCANUMAB, AMILOMOTIDE, BAPINEUZUMAB, CRENEZUMAB. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL384465 | 10.15 | Ki | 0.07 | Preclinical |
| CHEMBL2152914 | 10.0 | IC50 | 0.1 | Preclinical |
| CHEMBL74704 | 9.96 | Ki | 0.11 | Preclinical |
| CHEMBL76112 | 9.89 | Ki | 0.13 | Preclinical |
| CHEMBL300172 | 9.85 | Ki | 0.14 | Preclinical |
| CHEMBL3989948 | 9.85 | IC50 | 0.14 | Clinical |
| CHEMBL292910 | 9.77 | Ki | 0.17 | Preclinical |
| CHEMBL6008112 | 9.77 | IC50 | 0.17 | Preclinical |
| CHEMBL305634 | 9.72 | Ki | 0.19 | Preclinical |
| CHEMBL1774642 | 9.7 | Ki | 0.2 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 1,147 | 919 | 5.8 |
| assay format | 289 | 632 | 7.1 |
| cell-based format | 152 | 221 | 6.8 |
| tissue-based format | 56 | 115 | 8.0 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 22 | 44 | 5.6 |
| assay format | 18 | 0 | — |
| tissue-based format | 4 | 0 | — |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell membrane format | 1 | 0 | — |