Compound Detail
CHEMBL566752
FLORBETABEN F18 💊 Approved Drug
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💊 Approved Drug
Basic Information
| ChEMBL ID | CHEMBL566752 |
| Name | FLORBETABEN F18 |
| Phase | Approved |
| Structure Type | MOL |
| InChI Key | NCWZOASIUQVOFA-FWZJPQCDSA-N |
| Therapeutic | ✓ Yes |
| Parent Compound | CHEMBL1908906 |
| Active Moiety | CHEMBL1908906 |
2
Targets
8
Activities
1
Assay Types
0
PK Parameters
16
Publications
6
Known Names
7
Indications
1
Mechanisms
Molecular Properties
359.4
MW (Da)
4.28
ALogP
4
HBA
1
HBD
39.7
PSA (Ų)
0.45
QED
0
Ro5 Violations
12
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| First Approval | 2014 |
| Availability | Prescription |
| Chirality | Achiral |
Mechanism of Action
| Mechanism | Action Type | Target | Direct | Efficacy |
|---|---|---|---|---|
| Diagnostic agent | - | - | ✓ | ✓ |
Indications
Alzheimer Disease Cognitive Dysfunction Cognitive Dysfunction Radionuclide Imaging Amyotrophic Lateral Sclerosis Dementia Parkinson Disease
ATC Classification
V09AX06
florbetaben (18F)
Level 1: VARIOUS
Level 2: DIAGNOSTIC RADIOPHARMACEUTICALS
Activity Summary
Ki 8 meas. best 8.66
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Amyloid-beta precursor protein CHEMBL2487 | Ki | 8.66 | 8.6525 | 2.2 | 4 |
| Unchecked CHEMBL612545 | Ki | 8.65 | 8.41 | 2.2 | 4 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Amyloid-beta precursor protein | Ki | = | 2.2 | nM | 8.66 | Binding affinity to human amyloid beta plaque | 24936237 |
| Amyloid-beta precursor protein | Ki | = | 2.22 | nM | 8.65 | Displacement of [18F]-amyvid from amyloid-beta aggregates in alzheimer's disease... | 22011144 |
| Unchecked | Ki | = | 2.22 | nM | 8.65 | Binding affinity to beta-amyloid | 23047223 |
| Amyloid-beta precursor protein | Ki | = | 2.22 | nM | 8.65 | Binding affinity to amyloid beta (1-42) aggregates in human Alzheimer's disease ... | 22236086 |
| Unchecked | Ki | = | 2.22 | nM | 8.65 | Binding affinity to amyloid beta (1-42) aggregates | 22236086 |
| Amyloid-beta precursor protein | Ki | = | 2.22 | nM | 8.65 | Displacement of [125I]IMPY from amyloid beta in brain homogenate of Alzheimer's ... | 23673220 |
| Unchecked | Ki | = | 6.7 | nM | 8.17 | Binding affinity to amyloid beta (1 to 42) peptide | 19757822 |
| Unchecked | Ki | = | 6.7 | nM | 8.17 | Displacement of [125I]-IMPY from amyloid beta (1 to 42) fibrils after 2 hrs by g... | 22974116 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 22974116 | 10.1021/jm300973k | Brain | 3 |
| 19757822 | 10.1021/jm901057p | Brain | 2 |
| 22236086 | 10.1021/jm201400q | Brain | 2 |
| 19757822 | 10.1021/jm901057p | Bone | 1 |
| 19757822 | 10.1021/jm901057p | Unchecked | 1 |
| 21428407 | 10.1021/jm200057u | Brain | 1 |
| 21885280 | 10.1016/j.bmcl.2011.08.003 | Brain | 1 |
| 24900362 | 10.1021/ml200123w | Brain | 1 |
| 22011144 | 10.1021/jm2009106 | Amyloid-beta precursor protein | 1 |
| 24936237 | 10.1021/ml300058m | Amyloid-beta precursor protein | 1 |
| 23047223 | 10.1016/j.ejmech.2012.08.031 | Unchecked | 1 |
| 22236086 | 10.1021/jm201400q | No relevant target | 1 |
| 22236086 | 10.1021/jm201400q | Amyloid-beta precursor protein | 1 |
| 22236086 | 10.1021/jm201400q | Unchecked | 1 |
| 22974116 | 10.1021/jm300973k | Unchecked | 1 |
| 23673220 | 10.1016/j.bmc.2013.04.028 | Amyloid-beta precursor protein | 1 |
Data from ChEMBL 36 via Core Engine