Assay Detail
Binding
CHEMBL2161137
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Binding affinity to amyloid beta (1-42) aggregates in human Alzheimer's disease brain sections
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and evaluation of ¹⁸F-labeled styryltriazole and resveratrol derivatives for β-amyloid plaque imaging.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 8.70 | 8.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL381642 | — | — | 1 | 8.92 |
| CHEMBL566752 | FLORBETABEN F18 | 4.0 | 1 | 8.65 |
| CHEMBL1774461 | FLORBETAPIR F 18 | 4.0 | 1 | 8.54 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL381642 | — | Ki | = | 1.2 | nM | 8.92 |
| CHEMBL566752 | FLORBETABEN F18 | Ki | = | 2.22 | nM | 8.65 |
| CHEMBL1774461 | FLORBETAPIR F 18 | Ki | = | 2.87 | nM | 8.54 |