Assay Detail
Binding
CHEMBL2065861
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to human amyloid beta plaque
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
The β-Amyloid Hypothesis in Alzheimer's Disease: Seeing Is Believing.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 8.86 | 9.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2042122 | FLUTEMETAMOL F 18 | 4.0 | 1 | 9.15 |
| CHEMBL207456 | PITTSBURGH COMPOUND B | 2.0 | 1 | 9.10 |
| CHEMBL566752 | FLORBETABEN F18 | 4.0 | 1 | 8.66 |
| CHEMBL1774461 | FLORBETAPIR F 18 | 4.0 | 1 | 8.54 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2042122 | FLUTEMETAMOL F 18 | Ki | = | 0.7 | nM | 9.15 |
| CHEMBL207456 | PITTSBURGH COMPOUND B | Ki | = | 0.8 | nM | 9.10 |
| CHEMBL566752 | FLORBETABEN F18 | Ki | = | 2.2 | nM | 8.66 |
| CHEMBL1774461 | FLORBETAPIR F 18 | Ki | = | 2.9 | nM | 8.54 |