Compound Detail
CHEMBL2042122
FLUTEMETAMOL F 18 💊 Approved Drug
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
💊 Approved Drug
Basic Information
| ChEMBL ID | CHEMBL2042122 |
| Name | FLUTEMETAMOL F 18 |
| Phase | Approved |
| Structure Type | MOL |
| InChI Key | VVECGOCJFKTUAX-HUYCHCPVSA-N |
| Parent Compound | CHEMBL579205 |
| Active Moiety | CHEMBL579205 |
2
Targets
5
Activities
2
Assay Types
0
PK Parameters
5
Publications
11
Known Names
5
Indications
1
Mechanisms
Molecular Properties
274.3
MW (Da)
3.85
ALogP
4
HBA
2
HBD
45.1
PSA (Ų)
0.75
QED
0
Ro5 Violations
2
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| First Approval | 2013 |
| Availability | Prescription |
| Chirality | Achiral |
Mechanism of Action
| Mechanism | Action Type | Target | Direct | Efficacy |
|---|---|---|---|---|
| Diagnostic agent | - | - | ✓ | ✓ |
Indications
Alzheimer Disease Cognitive Dysfunction Radionuclide Imaging Radionuclide Imaging Cardiomyopathies
ATC Classification
V09AX04
flutemetamol (18F)
Level 1: VARIOUS
Level 2: DIAGNOSTIC RADIOPHARMACEUTICALS
Activity Summary
Ki 4 meas. best 9.15
Kd 1 meas. best 8.17
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Amyloid-beta precursor protein CHEMBL2487 | Ki | 9.15 | 9.14 | 0.7 | 2 |
| Unchecked CHEMBL612545 | Ki | 9.13 | 9.13 | 0.7 | 2 |
| Unchecked CHEMBL612545 | Kd | 8.17 | 8.17 | 6.7 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Amyloid-beta precursor protein | Ki | = | 0.7 | nM | 9.15 | Binding affinity to human amyloid beta plaque | 24936237 |
| Amyloid-beta precursor protein | Ki | = | 0.74 | nM | 9.13 | Displacement of [18F]-amyvid from amyloid-beta aggregates in alzheimer's disease... | 22011144 |
| Unchecked | Ki | = | 0.74 | nM | 9.13 | Binding affinity to beta-amyloid | 23047223 |
| Unchecked | Ki | = | 0.74 | nM | 9.13 | Binding affinity to amyloid beta (1-42) aggregates | 22236086 |
| Unchecked | Kd | = | 6.7 | nM | 8.17 | Binding affinity to amyloid beta (unknown origin) | 35759679 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 22011144 | 10.1021/jm2009106 | Amyloid-beta precursor protein | 1 |
| 24936237 | 10.1021/ml300058m | Amyloid-beta precursor protein | 1 |
| 23047223 | 10.1016/j.ejmech.2012.08.031 | Unchecked | 1 |
| 22236086 | 10.1021/jm201400q | Unchecked | 1 |
| 35759679 | 10.1021/acs.jmedchem.1c01619 | Unchecked | 1 |
Data from ChEMBL 36 via Core Engine