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Assay Detail

CHEMBL5140800

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Binding affinity to amyloid beta (unknown origin)
20
Total Activities
19
Compounds Tested
3
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

Near-Infrared Fluorescent Probes as Imaging and Theranostic Modalities for Amyloid-Beta and Tau Aggregates in Alzheimer's Disease.
Rai H, Gupta S, Kumar S, Yang J, Singh SK, Ran C, Modi G.
J Med Chem (2022) 65 : 8550 -8595
PubMed 35759679 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Kd 11 7.39 8.77
Ki 7 7.38 10.15
IC50 2 8.55 8.70

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL384465 1 10.15
CHEMBL5193435 1 8.77
CHEMBL2181532 1 8.70
CHEMBL5184204 1 8.43
CHEMBL2181045 1 8.40
CHEMBL2042122 FLUTEMETAMOL F 18 4.0 1 8.17
CHEMBL1092856 2 8.00
CHEMBL5184841 1 7.85
CHEMBL5202340 1 7.80
CHEMBL5189537 1 7.60
CHEMBL5170723 1 7.48
CHEMBL5202030 1 7.35
CHEMBL5185252 1 7.03
CHEMBL5197388 1 6.77
CHEMBL300172 CHRYSAMINE G 1 6.43
CHEMBL5170177 1 6.19
CHEMBL5205353 1 6.01
CHEMBL5170091 1 5.85
CHEMBL5185606 1 5.82

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL384465 Ki = 0.07 nM 10.15
CHEMBL5193435 Kd = 1.7 nM 8.77
CHEMBL2181532 IC50 = 2.0 nM 8.70
CHEMBL5184204 Kd = 3.7 nM 8.43
CHEMBL2181045 IC50 = 4.0 nM 8.40
CHEMBL2042122 FLUTEMETAMOL F 18 Kd = 6.7 nM 8.17
CHEMBL1092856 Ki = 10.0 nM 8.00
CHEMBL5184841 Ki = 14.1 nM 7.85
CHEMBL5202340 Kd = 16.0 nM 7.80
CHEMBL5189537 Kd = 25.2 nM 7.60
CHEMBL5170723 Kd = 33.23 nM 7.48
CHEMBL5202030 Kd = 44.6 nM 7.35
CHEMBL1092856 Kd = 54.6 nM 7.26
CHEMBL5185252 Ki = 92.6 nM 7.03
CHEMBL5197388 Kd = 170.0 nM 6.77
CHEMBL300172 CHRYSAMINE G Ki = 370.0 nM 6.43
CHEMBL5170177 Ki = 645.2 nM 6.19
CHEMBL5205353 Ki = 978.2 nM 6.01
CHEMBL5170091 Kd = 1410.0 nM 5.85
CHEMBL5185606 Kd = 1500.0 nM 5.82