Compound Detail
CHEMBL5185606
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Basic Information
| ChEMBL ID | CHEMBL5185606 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | GSUKCSHLPOJCSI-QWICPJCYSA-N |
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
422.5
MW (Da)
4.37
ALogP
7
HBA
0
HBD
84.9
PSA (Ų)
0.42
QED
0
Ro5 Violations
10
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Kd 2 meas. best 5.99
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Unchecked CHEMBL612545 | Kd | 5.99 | 5.905 | 1020.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Unchecked | Kd | = | 1020.0 | nM | 5.99 | Binding affinity to tau protein (unknown origin) | 35759679 |
| Unchecked | Kd | = | 1500.0 | nM | 5.82 | Binding affinity to amyloid beta (unknown origin) | 35759679 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 35759679 | 10.1021/acs.jmedchem.1c01619 | Unchecked | 2 |
Data from ChEMBL 36 via Core Engine