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Assay Detail

CHEMBL5140786

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Binding affinity to tau protein (unknown origin)
14
Total Activities
14
Compounds Tested
2
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

Near-Infrared Fluorescent Probes as Imaging and Theranostic Modalities for Amyloid-Beta and Tau Aggregates in Alzheimer's Disease.
Rai H, Gupta S, Kumar S, Yang J, Singh SK, Ran C, Modi G.
J Med Chem (2022) 65 : 8550 -8595
PubMed 35759679 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Kd 11 6.96 8.92
IC50 3 7.75 8.85

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL5191211 1 8.92
CHEMBL2203332 1 8.85
CHEMBL5176436 1 8.54
CHEMBL2207756 1 8.29
CHEMBL5170723 1 7.37
CHEMBL5186506 1 7.36
CHEMBL2181532 1 7.28
CHEMBL2181045 1 7.27
CHEMBL1314043 1 6.90
CHEMBL5189537 1 6.89
CHEMBL5191473 1 6.11
CHEMBL5185606 1 5.99
CHEMBL5181217 1 5.72
CHEMBL5170091 1 4.30

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL5191211 Kd = 1.19 nM 8.92
CHEMBL2203332 IC50 = 1.41 nM 8.85
CHEMBL5176436 Kd = 2.86 nM 8.54
CHEMBL2207756 IC50 = 5.1 nM 8.29
CHEMBL5170723 Kd = 43.12 nM 7.37
CHEMBL5186506 Kd = 44.1 nM 7.36
CHEMBL2181532 Kd = 52.0 nM 7.28
CHEMBL2181045 Kd = 54.0 nM 7.27
CHEMBL1314043 Kd = 126.0 nM 6.90
CHEMBL5189537 Kd = 127.4 nM 6.89
CHEMBL5191473 IC50 = 770.0 nM 6.11
CHEMBL5185606 Kd = 1020.0 nM 5.99
CHEMBL5181217 Kd = 1900.0 nM 5.72
CHEMBL5170091 Kd = 50000.0 nM 4.30