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Compound Detail

CHEMBL5193435

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CN(C)c1ncc(/C=C/c2nc3cc(OCC[18F])ccc3[se]2)cn1
ChEMBL ↗ Properties Compare Identifier

Basic Information

ChEMBL ID CHEMBL5193435
Phase Preclinical
Structure Type MOL
InChI Key UKEDBKRKICTQNA-MKMIUZQCSA-N
Parent Compound CHEMBL5207165
Active Moiety CHEMBL5207165
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names

Molecular Properties

391.3
MW (Da)

Drug Information

Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C17H17FN4OSe
MW 390.31

Activity Summary

Kd 1 meas. best 8.77

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Unchecked
CHEMBL612545
 Kd 8.77 8.77 1.7 1

Activity Data Samples

Top measurements by pChEMBL value

Target Type Rel. Value Units pChEMBL Assay PubMed
Unchecked Kd = 1.7 nM 8.77 Binding affinity to amyloid beta (unknown origin) 35759679

Literature References

PubMed DOI Target Context # Activities
35759679 10.1021/acs.jmedchem.1c01619 Unchecked 1
35759679 10.1021/acs.jmedchem.1c01619 No relevant target 1

Data from ChEMBL 36 via Core Engine