Assay Detail
Binding
CHEMBL2161134
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Binding affinity to amyloid beta (1-42) aggregates
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Synthesis and evaluation of ¹⁸F-labeled styryltriazole and resveratrol derivatives for β-amyloid plaque imaging.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 9 | 8.48 | 9.13 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2042122 | FLUTEMETAMOL F 18 | 4.0 | 1 | 9.13 |
| CHEMBL2158613 | — | — | 1 | 9.10 |
| CHEMBL1092857 | — | — | 1 | 8.72 |
| CHEMBL566752 | FLORBETABEN F18 | 4.0 | 1 | 8.65 |
| CHEMBL1774461 | FLORBETAPIR F 18 | 4.0 | 1 | 8.54 |
| CHEMBL1671878 | — | — | 1 | 8.46 |
| CHEMBL599471 | — | — | 1 | 8.22 |
| CHEMBL71696 | — | — | 1 | 7.82 |
| CHEMBL1836951 | — | — | 1 | 7.71 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2042122 | FLUTEMETAMOL F 18 | Ki | = | 0.74 | nM | 9.13 |
| CHEMBL2158613 | — | Ki | = | 0.8 | nM | 9.10 |
| CHEMBL1092857 | — | Ki | = | 1.9 | nM | 8.72 |
| CHEMBL566752 | FLORBETABEN F18 | Ki | = | 2.22 | nM | 8.65 |
| CHEMBL1774461 | FLORBETAPIR F 18 | Ki | = | 2.87 | nM | 8.54 |
| CHEMBL1671878 | — | Ki | = | 3.5 | nM | 8.46 |
| CHEMBL599471 | — | Ki | = | 6.0 | nM | 8.22 |
| CHEMBL71696 | — | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL1836951 | — | Ki | = | 19.7 | nM | 7.71 |