Compound Detail
CHEMBL579205
FLUTEMETAMOL 💊 Approved Drug
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💊 Approved Drug
Basic Information
| ChEMBL ID | CHEMBL579205 |
| Name | FLUTEMETAMOL |
| Phase | Approved |
| Structure Type | MOL |
| InChI Key | VVECGOCJFKTUAX-UHFFFAOYSA-N |
1
Targets
2
Activities
2
Assay Types
0
PK Parameters
3
Publications
2
Known Names
2
Indications
Molecular Properties
274.3
MW (Da)
3.85
ALogP
4
HBA
2
HBD
45.1
PSA (Ų)
0.75
QED
0
Ro5 Violations
2
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| First Approval | 2013 |
| Availability | Prescription |
| Chirality | Achiral |
Indications
Alzheimer Disease Breast Neoplasms
Activity Summary
IC50 1 meas. best 7.62
Ki 1 meas. best 9.13
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Amyloid-beta precursor protein CHEMBL2487 | Ki | 9.13 | 9.13 | 0.7 | 1 |
| Amyloid-beta precursor protein CHEMBL2487 | IC50 | 7.62 | 7.62 | 24.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Amyloid-beta precursor protein | Ki | = | 0.74 | nM | 9.13 | Binding affinity to Beta amyloid aggregates in Alzheimer's disease patient brain... | 19845387 |
| Amyloid-beta precursor protein | IC50 | = | 24.0 | nM | 7.62 | Displacement of [3H]AZD2184 from human amyloid beta(1 to 40) | 22647721 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 22647721 | 10.1016/j.bmcl.2012.05.011 | Amyloid-beta precursor protein | 2 |
| 19845387 | 10.1021/jm901039z | Amyloid-beta precursor protein | 1 |
| 22647721 | 10.1016/j.bmcl.2012.05.011 | Mus musculus | 1 |
Data from ChEMBL 36 via Core Engine