Assay Detail
Binding
CHEMBL2050034
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Displacement of [3H]AZD2184 from human amyloid beta(1 to 40)
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and evaluation of pyridylbenzofuran, pyridylbenzothiazole and pyridylbenzoxazole derivatives as ¹⁸F-PET imaging agents for β-amyloid plaques.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 7.38 | 7.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2048305 | — | — | 1 | 7.85 |
| CHEMBL93124 | PITTSBURGH COMPOUND B UNLABELLED | 2.0 | 1 | 7.72 |
| CHEMBL2048309 | — | — | 1 | 7.72 |
| CHEMBL570378 | — | — | 1 | 7.66 |
| CHEMBL579205 | FLUTEMETAMOL | 4.0 | 1 | 7.62 |
| CHEMBL2048308 | FLUTAFURANOL | 3.0 | 1 | 7.62 |
| CHEMBL2048310 | — | — | 1 | 7.52 |
| CHEMBL2048311 | — | — | 1 | 7.50 |
| CHEMBL2048314 | — | — | 1 | 7.50 |
| CHEMBL2048302 | — | — | 1 | 7.48 |
| CHEMBL2048300 | — | — | 1 | 7.46 |
| CHEMBL2048313 | — | — | 1 | 7.46 |
| CHEMBL2048304 | — | — | 1 | 7.36 |
| CHEMBL2048312 | — | — | 1 | 7.36 |
| CHEMBL2048303 | — | — | 1 | 7.18 |
| CHEMBL2048307 | — | — | 1 | 7.01 |
| CHEMBL2048306 | — | — | 1 | 6.91 |
| CHEMBL2048299 | — | — | 1 | 6.80 |
| CHEMBL2048301 | — | — | 1 | 6.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2048305 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL93124 | PITTSBURGH COMPOUND B UNLABELLED | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL2048309 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL570378 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL579205 | FLUTEMETAMOL | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL2048308 | FLUTAFURANOL | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL2048310 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL2048311 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL2048314 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL2048302 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL2048300 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL2048313 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL2048304 | — | IC50 | = | 44.0 | nM | 7.36 |
| CHEMBL2048312 | — | IC50 | = | 44.0 | nM | 7.36 |
| CHEMBL2048303 | — | IC50 | = | 66.0 | nM | 7.18 |
| CHEMBL2048307 | — | IC50 | = | 98.0 | nM | 7.01 |
| CHEMBL2048306 | — | IC50 | = | 124.0 | nM | 6.91 |
| CHEMBL2048299 | — | IC50 | = | 158.0 | nM | 6.80 |
| CHEMBL2048301 | — | IC50 | = | 395.0 | nM | 6.40 |