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Assay Detail

CHEMBL1039059

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Binding affinity to Beta amyloid aggregates in Alzheimer's disease patient brain by competitive binding assay
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Amyloid-beta precursor protein (CHEMBL2487)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

18F stilbenes and styrylpyridines for PET imaging of A beta plaques in Alzheimer's disease: a miniperspective.
Kung HF, Choi SR, Qu W, Zhang W, Skovronsky D.
J Med Chem (2010) 53 : 933 -941
PubMed 19845387 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 28 8.25 9.13

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL579205 FLUTEMETAMOL 4.0 1 9.13
CHEMBL93124 PITTSBURGH COMPOUND B UNLABELLED 2.0 1 9.06
CHEMBL93334 1 8.89
CHEMBL78012 1 8.89
CHEMBL570378 1 8.77
CHEMBL570610 1 8.70
CHEMBL566723 1 8.65
CHEMBL565657 1 8.64
CHEMBL381642 1 8.62
CHEMBL566709 1 8.54
CHEMBL1774461 FLORBETAPIR F 18 4.0 1 8.54
CHEMBL566296 1 8.36
CHEMBL567746 1 8.35
CHEMBL373236 1 8.30
CHEMBL570606 1 8.22
CHEMBL576655 1 8.12
CHEMBL565623 1 8.11
CHEMBL566917 1 8.09
CHEMBL566711 1 8.05
CHEMBL565658 1 7.91
CHEMBL585301 1 7.73
CHEMBL565281 1 7.66
CHEMBL81999 1 7.66
CHEMBL567614 1 7.50
CHEMBL570608 1 7.20
CHEMBL207649 1 6.76
CHEMBL224392 THIOFLAVIN T 1 -
CHEMBL300172 CHRYSAMINE G 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL579205 FLUTEMETAMOL Ki = 0.74 nM 9.13
CHEMBL93124 PITTSBURGH COMPOUND B UNLABELLED Ki = 0.87 nM 9.06
CHEMBL93334 Ki = 1.28 nM 8.89
CHEMBL78012 Ki = 1.29 nM 8.89
CHEMBL570378 Ki = 1.7 nM 8.77
CHEMBL570610 Ki = 2.0 nM 8.70
CHEMBL566723 Ki = 2.22 nM 8.65
CHEMBL565657 Ki = 2.3 nM 8.64
CHEMBL381642 Ki = 2.4 nM 8.62
CHEMBL566709 Ki = 2.9 nM 8.54
CHEMBL1774461 FLORBETAPIR F 18 Ki = 2.87 nM 8.54
CHEMBL566296 Ki = 4.4 nM 8.36
CHEMBL567746 Ki = 4.5 nM 8.35
CHEMBL373236 Ki = 5.0 nM 8.30
CHEMBL570606 Ki = 6.0 nM 8.22
CHEMBL576655 Ki = 7.5 nM 8.12
CHEMBL565623 Ki = 7.7 nM 8.11
CHEMBL566917 Ki = 8.2 nM 8.09
CHEMBL566711 Ki = 9.0 nM 8.05
CHEMBL565658 Ki = 12.2 nM 7.91
CHEMBL585301 Ki = 18.5 nM 7.73
CHEMBL565281 Ki = 22.0 nM 7.66
CHEMBL81999 Ki = 22.0 nM 7.66
CHEMBL567614 Ki = 32.0 nM 7.50
CHEMBL570608 Ki = 63.0 nM 7.20
CHEMBL207649 Ki = 172.0 nM 6.76
CHEMBL224392 THIOFLAVIN T Ki > 1000.0 nM -
CHEMBL300172 CHRYSAMINE G Ki > 1000.0 nM -