Assay Detail
Binding
CHEMBL2092540
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to beta-amyloid
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
¹⁸F-labeled 2-phenylquinoxaline derivatives as potential positron emission tomography probes for in vivo imaging of β-amyloid plaques.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 8.73 | 9.13 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2042122 | FLUTEMETAMOL F 18 | 4.0 | 1 | 9.13 |
| CHEMBL207456 | PITTSBURGH COMPOUND B | 2.0 | 1 | 9.06 |
| CHEMBL1836951 | — | — | 1 | 8.77 |
| CHEMBL566752 | FLORBETABEN F18 | 4.0 | 1 | 8.65 |
| CHEMBL1774461 | FLORBETAPIR F 18 | 4.0 | 1 | 8.54 |
| CHEMBL599471 | — | — | 1 | 8.22 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2042122 | FLUTEMETAMOL F 18 | Ki | = | 0.74 | nM | 9.13 |
| CHEMBL207456 | PITTSBURGH COMPOUND B | Ki | = | 0.87 | nM | 9.06 |
| CHEMBL1836951 | — | Ki | = | 1.7 | nM | 8.77 |
| CHEMBL566752 | FLORBETABEN F18 | Ki | = | 2.22 | nM | 8.65 |
| CHEMBL1774461 | FLORBETAPIR F 18 | Ki | = | 2.87 | nM | 8.54 |
| CHEMBL599471 | — | Ki | = | 6.0 | nM | 8.22 |