Assay Detail
Binding
CHEMBL2045349
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [18F]-amyvid from amyloid-beta aggregates in alzheimer's disease patient brain homogenates after 1 hr
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Tissue | Brain |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Multidentate (18)F-polypegylated styrylpyridines as imaging agents for Aβ plaques in cerebral amyloid angiopathy (CAA).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 13 | 8.33 | 9.13 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2042122 | FLUTEMETAMOL F 18 | 4.0 | 1 | 9.13 |
| CHEMBL207456 | PITTSBURGH COMPOUND B | 2.0 | 1 | 9.06 |
| CHEMBL78012 | — | — | 1 | 8.89 |
| CHEMBL566752 | FLORBETABEN F18 | 4.0 | 1 | 8.65 |
| CHEMBL2042123 | — | — | 1 | 8.64 |
| CHEMBL1774461 | FLORBETAPIR F 18 | 4.0 | 1 | 8.54 |
| CHEMBL381642 | — | — | 1 | 8.50 |
| CHEMBL2042124 | — | — | 1 | 8.49 |
| CHEMBL2042245 | — | — | 1 | 8.41 |
| CHEMBL2042125 | — | — | 1 | 8.11 |
| CHEMBL2042246 | — | — | 1 | 7.15 |
| CHEMBL2042247 | — | — | 1 | 6.33 |
| CHEMBL2042248 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2042122 | FLUTEMETAMOL F 18 | Ki | = | 0.74 | nM | 9.13 |
| CHEMBL207456 | PITTSBURGH COMPOUND B | Ki | = | 0.87 | nM | 9.06 |
| CHEMBL78012 | — | Ki | = | 1.29 | nM | 8.89 |
| CHEMBL566752 | FLORBETABEN F18 | Ki | = | 2.22 | nM | 8.65 |
| CHEMBL2042123 | — | Ki | = | 2.3 | nM | 8.64 |
| CHEMBL1774461 | FLORBETAPIR F 18 | Ki | = | 2.87 | nM | 8.54 |
| CHEMBL381642 | — | Ki | = | 3.18 | nM | 8.50 |
| CHEMBL2042124 | — | Ki | = | 3.24 | nM | 8.49 |
| CHEMBL2042245 | — | Ki | = | 3.86 | nM | 8.41 |
| CHEMBL2042125 | — | Ki | = | 7.71 | nM | 8.11 |
| CHEMBL2042246 | — | Ki | = | 71.2 | nM | 7.15 |
| CHEMBL2042247 | — | Ki | = | 468.0 | nM | 6.33 |
| CHEMBL2042248 | — | Ki | > | 1000.0 | nM | - |