Assay Detail
Binding
CHEMBL2399573
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [125I]IMPY from amyloid beta in brain homogenate of Alzheimer's disease patient after 2 hrs by gamma counting analysis
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Tissue | Brain |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and biological evaluation of 18F-labled 2-phenylindole derivatives as PET imaging probes for β-amyloid plaques.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 2 | 8.60 | 8.65 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL566752 | FLORBETABEN F18 | 4.0 | 1 | 8.65 |
| CHEMBL1774461 | FLORBETAPIR F 18 | 4.0 | 1 | 8.54 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL566752 | FLORBETABEN F18 | Ki | = | 2.22 | nM | 8.65 |
| CHEMBL1774461 | FLORBETAPIR F 18 | Ki | = | 2.87 | nM | 8.54 |