Assay Detail
Binding
CHEMBL3760764
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Displacement of [125I]BOB-4 from Amyloid beta (1 to 42) (unknown origin)
22
Total Activities
11
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Preliminary evaluation of fluoro-pegylated benzyloxybenzenes for quantification of β-amyloid plaques by positron emission tomography.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 11 | 7.05 | 7.94 |
| Inhibition | 11 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1908919 | FLORBETAPIR | 4.0 | 2 | 7.94 |
| CHEMBL3760007 | — | — | 2 | 7.68 |
| CHEMBL3758709 | — | — | 2 | 7.59 |
| CHEMBL78012 | — | — | 2 | 7.49 |
| CHEMBL93124 | PITTSBURGH COMPOUND B UNLABELLED | 2.0 | 2 | 7.41 |
| CHEMBL3759263 | — | — | 2 | 6.93 |
| CHEMBL3758500 | — | — | 2 | 6.82 |
| CHEMBL3758630 | — | — | 2 | 6.72 |
| CHEMBL3759510 | — | — | 2 | 6.45 |
| CHEMBL3759176 | — | — | 2 | 6.36 |
| CHEMBL3759854 | — | — | 2 | 6.11 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1908919 | FLORBETAPIR | Ki | = | 11.4 | nM | 7.94 |
| CHEMBL3760007 | — | Ki | = | 21.0 | nM | 7.68 |
| CHEMBL3758709 | — | Ki | = | 25.7 | nM | 7.59 |
| CHEMBL78012 | — | Ki | = | 32.2 | nM | 7.49 |
| CHEMBL93124 | PITTSBURGH COMPOUND B UNLABELLED | Ki | = | 38.8 | nM | 7.41 |
| CHEMBL3759263 | — | Ki | = | 118.5 | nM | 6.93 |
| CHEMBL3758500 | — | Ki | = | 152.6 | nM | 6.82 |
| CHEMBL3758630 | — | Ki | = | 191.1 | nM | 6.72 |
| CHEMBL3759510 | — | Ki | = | 357.7 | nM | 6.45 |
| CHEMBL3759176 | — | Ki | = | 437.9 | nM | 6.36 |
| CHEMBL3759854 | — | Ki | = | 770.1 | nM | 6.11 |
| CHEMBL3758709 | — | Inhibition | - | % | - | |
| CHEMBL3758630 | — | Inhibition | - | % | - | |
| CHEMBL3759510 | — | Inhibition | - | % | - | |
| CHEMBL3759263 | — | Inhibition | - | % | - | |
| CHEMBL3759176 | — | Inhibition | - | % | - | |
| CHEMBL3759854 | — | Inhibition | - | % | - | |
| CHEMBL3760007 | — | Inhibition | - | % | - | |
| CHEMBL3758500 | — | Inhibition | - | % | - | |
| CHEMBL78012 | — | Inhibition | - | % | - | |
| CHEMBL93124 | PITTSBURGH COMPOUND B UNLABELLED | Inhibition | - | % | - | |
| CHEMBL1908919 | FLORBETAPIR | Inhibition | - | % | - |