Assay Detail
Binding
CHEMBL2409975
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Displacement of [125I]IMPY from amyloid beta (1 to 42) (unknown origin) after 3 hrs by gamma counting
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Structure-Activity Relationships and in Vivo Evaluation of Quinoxaline Derivatives for PET Imaging of β-Amyloid Plaques.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 7.31 | 9.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2407616 | — | — | 1 | 9.05 |
| CHEMBL78012 | — | — | 1 | 8.14 |
| CHEMBL1908919 | FLORBETAPIR | 4.0 | 1 | 7.89 |
| CHEMBL2407615 | — | — | 1 | 7.80 |
| CHEMBL2407623 | — | — | 1 | 6.96 |
| CHEMBL2407624 | — | — | 1 | 6.62 |
| CHEMBL2407625 | — | — | 1 | 6.12 |
| CHEMBL2407626 | — | — | 1 | 5.93 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2407616 | — | Ki | = | 0.895 | nM | 9.05 |
| CHEMBL78012 | — | Ki | = | 7.21 | nM | 8.14 |
| CHEMBL1908919 | FLORBETAPIR | Ki | = | 12.8 | nM | 7.89 |
| CHEMBL2407615 | — | Ki | = | 15.7 | nM | 7.80 |
| CHEMBL2407623 | — | Ki | = | 111.0 | nM | 6.96 |
| CHEMBL2407624 | — | Ki | = | 242.0 | nM | 6.62 |
| CHEMBL2407625 | — | Ki | = | 758.0 | nM | 6.12 |
| CHEMBL2407626 | — | Ki | = | 1180.0 | nM | 5.93 |