Assay Detail
Functional
CHEMBL4733474
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of erastin-induced ferroptosis in human HT-1080 cells assessed as cell viability incubated for 48 hrs by MTT assay
98
Total Activities
98
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HT-1080 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Structure-activity relationship studies of phenothiazine derivatives as a new class of ferroptosis inhibitors together with the therapeutic effect in an ischemic stroke model.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 98 | 7.41 | 9.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4754158 | — | — | 1 | 9.30 |
| CHEMBL4748592 | — | — | 1 | 8.40 |
| CHEMBL4747920 | — | — | 1 | 8.30 |
| CHEMBL4750813 | — | — | 1 | 8.30 |
| CHEMBL4743554 | — | — | 1 | 8.30 |
| CHEMBL4793040 | — | — | 1 | 8.30 |
| CHEMBL4750992 | — | — | 1 | 8.30 |
| CHEMBL4760962 | — | — | 1 | 8.22 |
| CHEMBL4791794 | — | — | 1 | 8.22 |
| CHEMBL4752574 | — | — | 1 | 8.22 |
| CHEMBL4750463 | — | — | 1 | 8.22 |
| CHEMBL4788181 | — | — | 1 | 8.22 |
| CHEMBL4746877 | — | — | 1 | 8.15 |
| CHEMBL4782284 | — | — | 1 | 8.05 |
| CHEMBL4760238 | — | — | 1 | 8.05 |
| CHEMBL4792206 | — | — | 1 | 7.92 |
| CHEMBL4782741 | — | — | 1 | 7.89 |
| CHEMBL4744355 | — | — | 1 | 7.89 |
| CHEMBL4749286 | — | — | 1 | 7.89 |
| CHEMBL4761414 | — | — | 1 | 7.85 |
| CHEMBL4785795 | — | — | 1 | 7.85 |
| CHEMBL4798733 | — | — | 1 | 7.85 |
| CHEMBL4741152 | — | — | 1 | 7.82 |
| CHEMBL4748182 | — | — | 1 | 7.82 |
| CHEMBL4746229 | — | — | 1 | 7.80 |
| CHEMBL4744457 | — | — | 1 | 7.80 |
| CHEMBL4783979 | — | — | 1 | 7.77 |
| CHEMBL4784854 | — | — | 1 | 7.77 |
| CHEMBL4795684 | — | — | 1 | 7.77 |
| CHEMBL4784301 | — | — | 1 | 7.77 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4754158 | — | EC50 | = | 0.5 | nM | 9.30 |
| CHEMBL4748592 | — | EC50 | = | 4.0 | nM | 8.40 |
| CHEMBL4750813 | — | EC50 | = | 5.0 | nM | 8.30 |
| CHEMBL4743554 | — | EC50 | = | 5.0 | nM | 8.30 |
| CHEMBL4793040 | — | EC50 | = | 5.0 | nM | 8.30 |
| CHEMBL4750992 | — | EC50 | = | 5.0 | nM | 8.30 |
| CHEMBL4747920 | — | EC50 | = | 5.0 | nM | 8.30 |
| CHEMBL4760962 | — | EC50 | = | 6.0 | nM | 8.22 |
| CHEMBL4791794 | — | EC50 | = | 6.0 | nM | 8.22 |
| CHEMBL4752574 | — | EC50 | = | 6.0 | nM | 8.22 |
| CHEMBL4750463 | — | EC50 | = | 6.0 | nM | 8.22 |
| CHEMBL4788181 | — | EC50 | = | 6.0 | nM | 8.22 |
| CHEMBL4746877 | — | EC50 | = | 7.0 | nM | 8.15 |
| CHEMBL4782284 | — | EC50 | = | 9.0 | nM | 8.05 |
| CHEMBL4760238 | — | EC50 | = | 9.0 | nM | 8.05 |
| CHEMBL4792206 | — | EC50 | = | 12.0 | nM | 7.92 |
| CHEMBL4782741 | — | EC50 | = | 13.0 | nM | 7.89 |
| CHEMBL4744355 | — | EC50 | = | 13.0 | nM | 7.89 |
| CHEMBL4749286 | — | EC50 | = | 13.0 | nM | 7.89 |
| CHEMBL4761414 | — | EC50 | = | 14.0 | nM | 7.85 |
| CHEMBL4785795 | — | EC50 | = | 14.0 | nM | 7.85 |
| CHEMBL4798733 | — | EC50 | = | 14.0 | nM | 7.85 |
| CHEMBL4741152 | — | EC50 | = | 15.0 | nM | 7.82 |
| CHEMBL4748182 | — | EC50 | = | 15.0 | nM | 7.82 |
| CHEMBL4744457 | — | EC50 | = | 16.0 | nM | 7.80 |
| CHEMBL4746229 | — | EC50 | = | 16.0 | nM | 7.80 |
| CHEMBL4783979 | — | EC50 | = | 17.0 | nM | 7.77 |
| CHEMBL4784854 | — | EC50 | = | 17.0 | nM | 7.77 |
| CHEMBL4795684 | — | EC50 | = | 17.0 | nM | 7.77 |
| CHEMBL4784301 | — | EC50 | = | 17.0 | nM | 7.77 |
| CHEMBL4753513 | — | EC50 | = | 17.0 | nM | 7.77 |
| CHEMBL4751246 | — | EC50 | = | 17.0 | nM | 7.77 |
| CHEMBL4748738 | — | EC50 | = | 17.0 | nM | 7.77 |
| CHEMBL4785550 | — | EC50 | = | 18.0 | nM | 7.75 |
| CHEMBL4745484 | — | EC50 | = | 18.0 | nM | 7.75 |
| CHEMBL4796151 | — | EC50 | = | 19.0 | nM | 7.72 |
| CHEMBL4778775 | — | EC50 | = | 19.0 | nM | 7.72 |
| CHEMBL4790196 | — | EC50 | = | 20.0 | nM | 7.70 |
| CHEMBL4784394 | — | EC50 | = | 21.0 | nM | 7.68 |
| CHEMBL4798099 | — | EC50 | = | 21.0 | nM | 7.68 |
| CHEMBL4745443 | — | EC50 | = | 22.0 | nM | 7.66 |
| CHEMBL4753462 | — | EC50 | = | 22.0 | nM | 7.66 |
| CHEMBL4762750 | — | EC50 | = | 24.0 | nM | 7.62 |
| CHEMBL4778927 | — | EC50 | = | 25.0 | nM | 7.60 |
| CHEMBL4763148 | — | EC50 | = | 25.0 | nM | 7.60 |
| CHEMBL4749099 | — | EC50 | = | 25.0 | nM | 7.60 |
| CHEMBL4745943 | — | EC50 | = | 28.0 | nM | 7.55 |
| CHEMBL4759402 | — | EC50 | = | 30.0 | nM | 7.52 |
| CHEMBL4797413 | — | EC50 | = | 30.0 | nM | 7.52 |
| CHEMBL4785745 | — | EC50 | = | 32.0 | nM | 7.50 |