Review anchor
Polyunsaturated fatty acid lipoxygenase ALOX15
SINGLE PROTEIN · Oryctolagus cuniculus
As of 2026-09-14
Evidence Snapshot
Polyunsaturated fatty acid lipoxygenase ALOX15
CHEMBL4358
SINGLE PROTEIN
Oryctolagus cuniculus
Identity Layer
Cross-source identity
Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Polyunsaturated fatty acid lipoxygenase ALOX15 as ChEMBL target CHEMBL4358, mapped to UniProt P12530. Disease framing currently uses the Open Targets-ready proxy contract.
ChEMBL target ID
CHEMBL4358
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine
As of 2026-09-14
www.ebi.ac.uk
UniProt accession
P12530
Polyunsaturated fatty acid lipoxygenase ALOX15
UniProt accession via ChEMBL component mapping
As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy
As of 2026-09-14
www.ebi.ac.uk
Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.
Review-ready Target Rationale
Why Polyunsaturated fatty acid lipoxygenase ALOX15 matters
Polyunsaturated fatty acid lipoxygenase ALOX15 is reviewed as Polyunsaturated fatty acid lipoxygenase ALOX15 (UniProt P12530); the current evidence base includes 32 approved drugs, 1017 compounds, and 35 assays, with lead potency reaching pChEMBL 8.8.
Protein context
Polyunsaturated fatty acid lipoxygenase ALOX15
Polyunsaturated fatty acid lipoxygenase ALOX15 Sequence length is 663 aa.
Review this target as Polyunsaturated fatty acid lipoxygenase ALOX15, mapped to UniProt P12530. Sequence length is 663 aa.
Protein source · UniProt accession via ChEMBL component mapping
UniProt P12530
Protein
Disease context
Disease signal
Disease relevance is not yet populated for this evidence card.
This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
ChEMBL target recordActivity base
Portfolio and assay base
ChEMBL currently tracks 32 approved drugs, 1017 compounds, and 35 assays for this target. The dominant activity type is IC50. CHEMBL1796851 is the current potency anchor at pChEMBL 8.8.
Use CHEMBL1796851 as the tractability anchor when discussing potency (pChEMBL 8.8).
Activity source · ChEMBL 36 via Core Engine
32 approved
pChEMBL 8.8
Source Guidance
Start with the right source
Pick the first block or linked source that matches the review question in front of you.
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Review-ready Target Rationale
One-page rationale with as-of-date and attribution
Start with the review rationale when you need to explain why Polyunsaturated fatty acid lipoxygenase ALOX15 matters before drilling into raw source blocks.
Jump to Review RationaleNeed stable protein naming or accession mapping?
UniProt Target Context
UniProt accession via ChEMBL component mapping
Go back to the target snapshot when you need the naming and mapping contract behind UniProt P12530, not just the summarized rationale.
Open Protein ContextNeed disease fit or evidence level for program framing?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy
Use the target snapshot disease block when you need the disease program and supporting signals, not only the card summary.
Open Disease ContextSnapshot State
No project snapshot selected. Export uses the live evidence card state.
1017
Total Compounds
35
Total Assays
32
Approved Drugs
IC50: 1117.0, KI: 840.0
Activity Types
pChEMBL Activity Distribution
Top 5 Inhibitors (by pChEMBL)
| Structure | Compound | pChEMBL | Type | Phase |
|---|---|---|---|---|
|
|
No preferred name
CHEMBL1796851
|
8.8 | IC50 | — |
|
|
No preferred name
CHEMBL1796845
|
8.8 | IC50 | — |
|
|
No preferred name
CHEMBL1796849
|
8.7 | IC50 | — |
|
|
No preferred name
CHEMBL1796846
|
8.7 | IC50 | — |
|
|
No preferred name
CHEMBL1796850
|
8.6 | IC50 | — |
Approved Drugs
| Structure | Compound | First Approval |
|---|---|---|
|
|
MIFEPRISTONE
CHEMBL1276308
|
2000 |
|
|
TANNIC ACID
CHEMBL506247
|
1982 |
|
|
DOBUTAMINE
CHEMBL926
|
1978 |
Source Header