Heme oxygenase 1 · SINGLE PROTEIN · Rattus norvegicus
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As of 2026-09-14Protein identity stays anchored to UniProt P06762. Use UniProt P06762 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P06762 as the stable identity anchor, then attach disease evidence before program review.
Heme oxygenase 1
Review this target as Heme oxygenase 1, mapped to UniProt P06762. Sequence length is 289 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Heme oxygenase 1 as ChEMBL target CHEMBL5035, mapped to UniProt P06762. Disease framing currently uses the Open Targets-ready proxy contract.
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Start here when your first question is whether Heme oxygenase 1 is the right protein anchor across sources, using UniProt P06762 as the stable mapping.
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| Preferred Name | Heme oxygenase 1 |
| Target Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
| UniProt | P06762 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Heme oxygenase 1 |
| UniProt Accession | P06762 |
| Component Type | Protein |
| Sequence Length | 289 aa |
Heme oxygenase 1
Review this target as Heme oxygenase 1, mapped to UniProt P06762. Sequence length is 289 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL1188560 | 7.22 | IC50 | 60.0 | Preclinical |
| CHEMBL4161975 | 7.22 | IC50 | 60.0 | Preclinical |
| CHEMBL536746 | 7.22 | IC50 | 60.0 | Preclinical |
| CHEMBL540883 | 6.96 | IC50 | 110.0 | Preclinical |
| CHEMBL536745 | 6.85 | IC50 | 140.0 | Preclinical |
| CHEMBL4586392 | 6.65 | IC50 | 225.0 | Preclinical |
| CHEMBL4583097 | 6.62 | IC50 | 240.0 | Preclinical |
| CHEMBL4520773 | 6.6 | IC50 | 250.0 | Preclinical |
| CHEMBL4166126 | 6.57 | IC50 | 270.0 | Preclinical |
| CHEMBL581354 | 6.57 | IC50 | 270.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| microsome format | 12 | 125 | 5.5 |
| tissue-based format | 7 | 50 | 5.2 |
| single protein format | 1 | 8 | 5.3 |
| subcellular format | 1 | 18 | 5.0 |