Assay Detail
Functional
CHEMBL858091
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro agonist potency towards Alpha-1D adrenergic receptor in rat aorta
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Tissue | Aorta |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Synthesis and in vitro characterization of N-[5-(4,5-dihydro-1H-imidazol-2-yl)-2-hydroxy-5,6,7,8- tetrahydronaphthalen-1-yl]methanesulfonamide and its enantiomers: a novel selective alpha 1A receptor agonist.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 6 | 6.28 | 7.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1437 | NOREPINEPHRINE | 4.0 | 1 | 7.92 |
| CHEMBL1215 | PHENYLEPHRINE | 4.0 | 1 | 6.81 |
| CHEMBL336161 | — | — | 1 | 5.99 |
| CHEMBL109783 | — | — | 1 | 5.59 |
| CHEMBL762 | OXYMETAZOLINE | 4.0 | 1 | 5.08 |
| CHEMBL133451 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1437 | NOREPINEPHRINE | EC50 | = | 12.02 | nM | 7.92 |
| CHEMBL1215 | PHENYLEPHRINE | EC50 | = | 154.88 | nM | 6.81 |
| CHEMBL336161 | — | EC50 | = | 1023.29 | nM | 5.99 |
| CHEMBL109783 | — | EC50 | = | 2570.4 | nM | 5.59 |
| CHEMBL762 | OXYMETAZOLINE | EC50 | = | 8317.64 | nM | 5.08 |
| CHEMBL133451 | — | EC50 | < | 100000.0 | nM | - |