Beta-1 adrenergic receptor · SINGLE PROTEIN · Rattus norvegicus
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As of 2026-09-13Protein identity stays anchored to UniProt P18090. Use UniProt P18090 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P18090 as the stable identity anchor, then attach disease evidence before program review.
Beta-1 adrenergic receptor
Review this target as Beta-1 adrenergic receptor, mapped to UniProt P18090. Sequence length is 466 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Beta-1 adrenergic receptor as ChEMBL target CHEMBL3252, mapped to UniProt P18090. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Beta-1 adrenergic receptor |
| Target Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
| UniProt | P18090 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Beta-1 adrenergic receptor |
| UniProt Accession | P18090 |
| Component Type | Protein |
| Sequence Length | 466 aa |
Beta-1 adrenergic receptor
Review this target as Beta-1 adrenergic receptor, mapped to UniProt P18090. Sequence length is 466 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL378501 | 10.4 | Ki | 0.03981 | Preclinical |
| CHEMBL210309 | 10.2 | Kd | 0.0631 | Preclinical |
| CHEMBL543955 | 9.56 | Kd | 0.2754 | Preclinical |
| CHEMBL267375 | 9.3 | Kd | 0.5012 | Preclinical |
| CHEMBL723 | 9.09 | Ki | 0.81 | Approved |
| CHEMBL280822 | 8.9 | Ki | 1.259 | Preclinical |
| CHEMBL542536 | 8.7 | Kd | 1.995 | Preclinical |
| CHEMBL477466 | 8.7 | Ki | 2.0 | Preclinical |
| CHEMBL27 | 8.62 | Kd | 2.399 | Approved |
| CHEMBL423 | 8.53 | Kd | 2.951 | Approved |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 13 | 47 | 5.5 |
| tissue-based format | 12 | 30 | 6.4 |
| single protein format | 11 | 12 | 6.5 |
| cell membrane format | 10 | 51 | 5.3 |
| cell-based format | 2 | 0 | — |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 18 | 34 | 7.2 |
| cell-based format | 5 | 8 | 7.6 |
| tissue-based format | 5 | 8 | 7.2 |
| organism-based format | 4 | 0 | — |