Assay Detail
Binding
CHEMBL642033
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Binding affinity against alpha 2-Adrenergic receptor in guinea pig cerebral cortical membranes by displacement of [3H]clonidine
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Syntheses and adrenergic activities of ring-fluorinated epinephrines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 7.24 | 8.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL42359 | — | — | 1 | 8.05 |
| CHEMBL1437 | NOREPINEPHRINE | 4.0 | 1 | 7.52 |
| CHEMBL287587 | — | — | 1 | 6.16 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL42359 | — | Ki | = | 9.0 | nM | 8.05 |
| CHEMBL1437 | NOREPINEPHRINE | Ki | = | 30.0 | nM | 7.52 |
| CHEMBL287587 | — | Ki | = | 700.0 | nM | 6.16 |