Assay Detail

CHEMBL648425

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Functional

Effective dose for contraction of rat aorta.

ChEMBL ↗

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Target

Adrenergic receptor alpha-1 (CHEMBL1907610) ↗

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Adrenergic receptor alpha-1 (CHEMBL1907610) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Adrenergic receptor alpha-1

CHEMBL1907610

Anchored from Assay target.

Protein identity Adrenergic receptor alpha-1

Disease frame Disease evidence pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Tissue	Aorta
Confidence	4 — Cell-line / Tissue
Curated By	Autocuration

Target

Adrenergic receptor alpha-1 (CHEMBL1907610) ↗

Type	PROTEIN FAMILY
Organism	Rattus norvegicus

Publication

Alpha- and beta-adrenoceptors: from the gene to the clinic. 2. Structure-activity relationships and therapeutic applications.

Ruffolo RR, Bondinell W, Hieble JP.
J Med Chem (1995) 38 : 3681 -3716
PubMed 7562902 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
EC50	1	8.92	8.92

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL1437	NOREPINEPHRINE	4.0	1	8.92

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL1437	NOREPINEPHRINE	EC50	=	1.2	nM	8.92