Beta-2 adrenergic receptor · SINGLE PROTEIN · Rattus norvegicus
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As of 2026-09-13Protein identity stays anchored to UniProt P10608. Use UniProt P10608 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P10608 as the stable identity anchor, then attach disease evidence before program review.
Beta-2 adrenergic receptor
Review this target as Beta-2 adrenergic receptor, mapped to UniProt P10608. Sequence length is 418 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Beta-2 adrenergic receptor as ChEMBL target CHEMBL3754, mapped to UniProt P10608. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Beta-2 adrenergic receptor |
| Target Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
| UniProt | P10608 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Beta-2 adrenergic receptor |
| UniProt Accession | P10608 |
| Component Type | Protein |
| Sequence Length | 418 aa |
Beta-2 adrenergic receptor
Review this target as Beta-2 adrenergic receptor, mapped to UniProt P10608. Sequence length is 418 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL434 | 10.0 | IC50 | 0.1 | Approved |
| CHEMBL284782 | 8.04 | IC50 | 9.1 | Preclinical |
| CHEMBL363325 | 7.92 | EC50 | 12.0 | Preclinical |
| CHEMBL244687 | 7.85 | EC50 | 14.0 | Preclinical |
| CHEMBL1800963 | 7.8 | EC50 | 16.0 | Preclinical |
| CHEMBL3247309 | 7.7 | Kd | 19.95 | Preclinical |
| CHEMBL83063 | 7.62 | IC50 | 23.99 | Approved |
| CHEMBL38486 | 7.52 | IC50 | 30.0 | Preclinical |
| CHEMBL143467 | 7.5 | Kd | 31.62 | Preclinical |
| CHEMBL229401 | 7.23 | EC50 | 59.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 10 | 0 | — |
| single protein format | 7 | 0 | — |
| cell membrane format | 6 | 9 | 5.8 |
| tissue-based format | 3 | 0 | — |
| assay format | 1 | 0 | — |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 12 | 13 | 6.4 |
| tissue-based format | 5 | 10 | 6.2 |
| assay format | 3 | 17 | 6.0 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 1 | 9 | 5.7 |