Compound Detail
CHEMBL143467
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL143467 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | OMSWREDBGOSTLF-UHFFFAOYSA-N |
3
Targets
3
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names
Molecular Properties
237.3
MW (Da)
1.99
ALogP
3
HBA
2
HBD
41.5
PSA (Ų)
0.76
QED
0
Ro5 Violations
7
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Kd 3 meas. best 7.5
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Beta-2 adrenergic receptor CHEMBL3754 | Kd | 7.5 | 7.5 | 31.6 | 1 |
| Beta-1 adrenergic receptor CHEMBL3252 | Kd | 7.2 | 7.2 | 63.1 | 1 |
| Beta-1 adrenergic receptor CHEMBL5471 | Kd | 7.2 | 7.2 | 63.1 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Beta-2 adrenergic receptor | Kd | = | 31.62 | nM | 7.5 | Antagonist activity at beta2 adrenergic receptor in isolated rat stomach fundus | 31488 |
| Beta-1 adrenergic receptor | Kd | = | 63.1 | nM | 7.2 | Activity at beta-1 adrenergic receptor | 1361581 |
| Beta-1 adrenergic receptor | Kd | = | 63.1 | nM | 7.2 | Antagonist activity at beta1 adrenergic receptor in isolated rat atria | 31488 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 1361581 | 10.1021/jm00103a004 | Beta-1 adrenergic receptor | 1 |
| 31488 | 10.1021/jm00207a025 | Beta-1 adrenergic receptor | 1 |
| 31488 | 10.1021/jm00207a025 | Beta-2 adrenergic receptor | 1 |
| 31488 | 10.1021/jm00207a025 | Unchecked | 1 |
Data from ChEMBL 36 via Core Engine