Assay Detail
Binding
CHEMBL654956
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Activity at beta-1 adrenergic receptor
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Computer-aided mapping of the beta-adrenoceptor. 1. Explanation for effect of para substitution on blocking activity at the beta-1-adrenoceptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 9 | 7.17 | 8.90 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL11171 | — | — | 1 | 8.90 |
| CHEMBL43405 | — | — | 1 | 8.20 |
| CHEMBL269219 | — | — | 1 | 7.60 |
| CHEMBL143467 | — | — | 1 | 7.20 |
| CHEMBL768 | ESMOLOL | 4.0 | 1 | 7.00 |
| CHEMBL24 | ATENOLOL | 4.0 | 1 | 6.80 |
| CHEMBL31608 | — | — | 1 | 6.50 |
| CHEMBL31036 | — | — | 1 | 6.30 |
| CHEMBL6995 | PRACTOLOL | 4.0 | 1 | 6.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL11171 | — | Kd | = | 1.259 | nM | 8.90 |
| CHEMBL43405 | — | Kd | = | 6.31 | nM | 8.20 |
| CHEMBL269219 | — | Kd | = | 25.12 | nM | 7.60 |
| CHEMBL143467 | — | Kd | = | 63.1 | nM | 7.20 |
| CHEMBL768 | ESMOLOL | Kd | = | 100.0 | nM | 7.00 |
| CHEMBL24 | ATENOLOL | Kd | = | 158.49 | nM | 6.80 |
| CHEMBL31608 | — | Kd | = | 316.23 | nM | 6.50 |
| CHEMBL31036 | — | Kd | = | 501.19 | nM | 6.30 |
| CHEMBL6995 | PRACTOLOL | Kd | = | 1000.0 | nM | 6.00 |