Assay Detail
Binding
CHEMBL873183
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Compound was evaluated for alpha adrenergic binding affinity towards Alpha-2 adrenergic receptor of rat brain
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Conformational effects on the activity of drugs. 13. A revision of previously proposed models for the activation of alpha- and beta-adrenergic receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 6.22 | 8.32 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1437 | NOREPINEPHRINE | 4.0 | 1 | 8.32 |
| CHEMBL7681 | — | — | 1 | 7.58 |
| CHEMBL7278 | — | — | 1 | 6.30 |
| CHEMBL6898 | — | — | 1 | 5.80 |
| CHEMBL7160 | — | — | 1 | 5.54 |
| CHEMBL268881 | — | — | 1 | 5.29 |
| CHEMBL434 | ISOPROTERENOL | 4.0 | 1 | 4.68 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1437 | NOREPINEPHRINE | Ki | = | 4.8 | nM | 8.32 |
| CHEMBL7681 | — | Ki | = | 26.0 | nM | 7.58 |
| CHEMBL7278 | — | Ki | = | 500.0 | nM | 6.30 |
| CHEMBL6898 | — | Ki | = | 1570.0 | nM | 5.80 |
| CHEMBL7160 | — | Ki | = | 2900.0 | nM | 5.54 |
| CHEMBL268881 | — | Ki | = | 5100.0 | nM | 5.29 |
| CHEMBL434 | ISOPROTERENOL | Ki | = | 21000.0 | nM | 4.68 |