Assay Detail
Functional
CHEMBL936722
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Agonist activity at human adrenergic beta3 receptor expressed in CHO cells assessed as [3H]cAMP levels by radiolabeled ligand based assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Stereospecific synthesis and bio-activity of novel beta(3)-adrenoceptor agonists and inverse agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 8.04 | 8.41 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL434 | ISOPROTERENOL | 4.0 | 1 | 8.41 |
| CHEMBL284782 | — | — | 1 | 8.23 |
| CHEMBL1437 | NOREPINEPHRINE | 4.0 | 1 | 8.20 |
| CHEMBL679 | EPINEPHRINE | 4.0 | 1 | 7.31 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL434 | ISOPROTERENOL | EC50 | = | 3.9 | nM | 8.41 |
| CHEMBL284782 | — | EC50 | = | 5.9 | nM | 8.23 |
| CHEMBL1437 | NOREPINEPHRINE | EC50 | = | 6.3 | nM | 8.20 |
| CHEMBL679 | EPINEPHRINE | EC50 | = | 49.0 | nM | 7.31 |