Assay Detail
Binding
CHEMBL643927
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The compound was evaluated for the inhibition of [3H]rauwolscine binding to alpha-2-adrenergic receptor from rat cortex
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Conformationally defined adrenergic agents. 2. Catechol imidazoline derivatives: biological effects at alpha 1 and alpha 2 adrenergic receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 7.36 | 8.48 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL545092 | — | — | 1 | 8.48 |
| CHEMBL543684 | — | — | 1 | 8.15 |
| CHEMBL1437 | NOREPINEPHRINE | 4.0 | 1 | 7.48 |
| CHEMBL544627 | — | — | 1 | 7.31 |
| CHEMBL554004 | — | — | 1 | 5.38 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL545092 | — | IC50 | = | 3.3 | nM | 8.48 |
| CHEMBL543684 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL1437 | NOREPINEPHRINE | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL544627 | — | IC50 | = | 49.0 | nM | 7.31 |
| CHEMBL554004 | — | IC50 | = | 4200.0 | nM | 5.38 |