Adrenergic receptor beta · PROTEIN FAMILY · Rattus norvegicus
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As of 2026-09-14Protein identity stays anchored to UniProt P18090. Use UniProt P18090 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P18090 as the stable identity anchor, then attach disease evidence before program review.
Beta-1 adrenergic receptor
Review this target as Adrenergic receptor beta, mapped to UniProt P18090. ChEMBL maps the protein component as Beta-1 adrenergic receptor. Sequence length is 466 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Adrenergic receptor beta as ChEMBL target CHEMBL2095166, mapped to UniProt P18090. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Adrenergic receptor beta |
| Target Type | PROTEIN FAMILY |
| Organism | Rattus norvegicus |
| UniProt | P18090 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Beta-1 adrenergic receptor |
| UniProt Accession | P18090 |
| Component Type | Protein |
| Sequence Length | 466 aa |
Beta-1 adrenergic receptor
Review this target as Adrenergic receptor beta, mapped to UniProt P18090. ChEMBL maps the protein component as Beta-1 adrenergic receptor. Sequence length is 466 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL157881 | 9.34 | Ki | 0.46 | Preclinical |
| CHEMBL348176 | 9.21 | Ki | 0.61 | Preclinical |
| CHEMBL452861 | 9.15 | Kd | 0.7 | Clinical |
| CHEMBL543099 | 9.05 | IC50 | 0.9 | Preclinical |
| CHEMBL348176 | 9.0 | Kd | 1.0 | Preclinical |
| CHEMBL553039 | 8.96 | IC50 | 1.09 | Preclinical |
| CHEMBL156754 | 8.92 | Kd | 1.2 | Preclinical |
| CHEMBL46136 | 8.89 | Kd | 1.3 | Preclinical |
| CHEMBL156628 | 8.85 | Kd | 1.4 | Preclinical |
| CHEMBL157881 | 8.8 | Kd | 1.6 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 56 | 40 | 7.7 |
| protein format | 32 | 18 | 6.9 |
| tissue-based format | 16 | 10 | 5.6 |
| cell membrane format | 13 | 24 | 6.4 |
| cell-based format | 3 | 11 | 7.0 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 16 | 9 | 7.1 |
| organism-based format | 9 | 0 | — |
| tissue-based format | 7 | 9 | 6.6 |
| cell-based format | 6 | 7 | 7.4 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 1 | 0 | — |