Assay Detail
Functional
CHEMBL936719
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Agonist activity at human adrenergic beta-3 receptor expressed in CHO cells assessed as cAMP levels by DELFIA method
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Stereospecific synthesis and bio-activity of novel beta(3)-adrenoceptor agonists and inverse agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 12 | 7.95 | 8.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL284782 | — | — | 1 | 8.96 |
| CHEMBL259361 | — | — | 1 | 8.57 |
| CHEMBL403711 | — | — | 1 | 8.47 |
| CHEMBL259858 | — | — | 1 | 8.42 |
| CHEMBL260393 | — | — | 1 | 8.41 |
| CHEMBL260392 | — | — | 1 | 8.31 |
| CHEMBL1437 | NOREPINEPHRINE | 4.0 | 1 | 8.26 |
| CHEMBL434 | ISOPROTERENOL | 4.0 | 1 | 8.24 |
| CHEMBL679 | EPINEPHRINE | 4.0 | 1 | 7.51 |
| CHEMBL402462 | — | — | 1 | 6.87 |
| CHEMBL260018 | — | — | 1 | 6.74 |
| CHEMBL260996 | — | — | 1 | 6.63 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL284782 | — | EC50 | = | 1.1 | nM | 8.96 |
| CHEMBL259361 | — | EC50 | = | 2.7 | nM | 8.57 |
| CHEMBL403711 | — | EC50 | = | 3.4 | nM | 8.47 |
| CHEMBL259858 | — | EC50 | = | 3.8 | nM | 8.42 |
| CHEMBL260393 | — | EC50 | = | 3.9 | nM | 8.41 |
| CHEMBL260392 | — | EC50 | = | 4.9 | nM | 8.31 |
| CHEMBL1437 | NOREPINEPHRINE | EC50 | = | 5.5 | nM | 8.26 |
| CHEMBL434 | ISOPROTERENOL | EC50 | = | 5.8 | nM | 8.24 |
| CHEMBL679 | EPINEPHRINE | EC50 | = | 31.0 | nM | 7.51 |
| CHEMBL402462 | — | EC50 | = | 136.0 | nM | 6.87 |
| CHEMBL260018 | — | EC50 | = | 181.0 | nM | 6.74 |
| CHEMBL260996 | — | EC50 | = | 235.0 | nM | 6.63 |