Assay Detail
Binding
CHEMBL648063
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Tested for binding affinity against alpha-2 adrenergic receptor in rat brain using [3H]- rauwolscine as radioligand
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Brain |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Conformationally restrained analogs of sympathomimetic catecholamines. Synthesis, conformational analysis, and adrenergic activity of isochroman derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 6.36 | 8.32 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1437 | NOREPINEPHRINE | 4.0 | 1 | 8.32 |
| CHEMBL99361 | — | — | 1 | 8.13 |
| CHEMBL105383 | — | — | 1 | 5.89 |
| CHEMBL105434 | — | — | 1 | 5.75 |
| CHEMBL322842 | — | — | 1 | 5.38 |
| CHEMBL434 | ISOPROTERENOL | 4.0 | 1 | 4.68 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1437 | NOREPINEPHRINE | Ki | = | 4.8 | nM | 8.32 |
| CHEMBL99361 | — | Ki | = | 7.4 | nM | 8.13 |
| CHEMBL105383 | — | Ki | = | 1280.0 | nM | 5.89 |
| CHEMBL105434 | — | Ki | = | 1780.0 | nM | 5.75 |
| CHEMBL322842 | — | Ki | = | 4120.0 | nM | 5.38 |
| CHEMBL434 | ISOPROTERENOL | Ki | = | 21000.0 | nM | 4.68 |