Skip to main content
Free research Free research Free compound review with research home and workspace preview
Quick search ChEMBL 36
Compound Detail

CHEMBL520313

Enter ChEMBL ID:
Free Research Context This compound will appear in recent viewed items on the research home for this browser.
Research home View demo workspace
CC(=O)O.NS(=O)(=O)c1ccccc1CCCCOCCCCCCNC[C@H](O)c1ccc(O)c(CO)c1

Basic Information

ChEMBL ID CHEMBL520313
Phase Preclinical
Structure Type MOL
InChI Key VAIBMXNTQZFQCJ-JIDHJSLPSA-N
Parent Compound CHEMBL1187778
Active Moiety CHEMBL1187778
4
Targets
6
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names

Molecular Properties

494.6
MW (Da)
2.75
ALogP
7
HBA
5
HBD
142.1
PSA (Ų)
0.21
QED
0
Ro5 Violations
17
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C27H42N2O8S
MW 554.71
Aromatic Rings 2
Heavy Atoms 34
NP-Likeness -0.13

Activity Summary

EC50 6 meas. best 9.1

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Beta-2 adrenergic receptor
CHEMBL210
EC50 9.1 9.1 0.8 1
Beta-1 adrenergic receptor
CHEMBL5471
EC50 8.6 8.6 2.5 1
Beta-1 adrenergic receptor
CHEMBL213
EC50 6.6 6.6 251.2 1
Beta-3 adrenergic receptor
CHEMBL246
EC50 6.3 6.3 501.2 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
19317397 10.1021/jm801016j Beta-1 adrenergic receptor 5
19317397 10.1021/jm801016j Beta-2 adrenergic receptor 2
19317397 10.1021/jm801016j Unchecked 2
19317397 10.1021/jm801016j Beta-3 adrenergic receptor 1

Data from ChEMBL 36 via Core Engine