Assay Detail
Functional
CHEMBL1246860
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate method
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Inhalation by design: novel ultra-long-acting β(2)-adrenoreceptor agonists for inhaled once-daily treatment of asthma and chronic obstructive pulmonary disease that utilize a sulfonamide agonist headgroup.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 22 | 10.18 | 10.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1242943 | — | — | 1 | 10.70 |
| CHEMBL1243189 | — | — | 1 | 10.64 |
| CHEMBL230490 | — | — | 1 | 10.62 |
| CHEMBL1243158 | — | — | 1 | 10.57 |
| CHEMBL1243348 | — | — | 1 | 10.49 |
| CHEMBL1243190 | — | — | 1 | 10.40 |
| CHEMBL1243256 | — | — | 1 | 10.40 |
| CHEMBL1243222 | — | — | 1 | 10.38 |
| CHEMBL1243101 | — | — | 1 | 10.35 |
| CHEMBL1243285 | — | — | 1 | 10.32 |
| CHEMBL1243407 | ZINTEROL | 2.0 | 1 | 10.27 |
| CHEMBL1243317 | — | — | 1 | 10.25 |
| CHEMBL402501 | — | — | 1 | 10.19 |
| CHEMBL1243347 | — | — | 1 | 10.18 |
| CHEMBL1263 | SALMETEROL | 4.0 | 1 | 10.15 |
| CHEMBL1243068 | — | — | 1 | 10.04 |
| CHEMBL1243035 | — | — | 1 | 9.89 |
| CHEMBL1243000 | — | — | 1 | 9.77 |
| CHEMBL1240965 | — | — | 1 | 9.68 |
| CHEMBL1240966 | — | — | 1 | 9.62 |
| CHEMBL1240967 | PF-00610355 | 2.0 | 1 | 9.59 |
| CHEMBL1242969 | — | — | 1 | 9.43 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1242943 | — | EC50 | = | 0.02 | nM | 10.70 |
| CHEMBL1243189 | — | EC50 | = | 0.023 | nM | 10.64 |
| CHEMBL230490 | — | EC50 | = | 0.024 | nM | 10.62 |
| CHEMBL1243158 | — | EC50 | = | 0.027 | nM | 10.57 |
| CHEMBL1243348 | — | EC50 | = | 0.032 | nM | 10.49 |
| CHEMBL1243190 | — | EC50 | = | 0.04 | nM | 10.40 |
| CHEMBL1243256 | — | EC50 | = | 0.04 | nM | 10.40 |
| CHEMBL1243222 | — | EC50 | = | 0.042 | nM | 10.38 |
| CHEMBL1243101 | — | EC50 | = | 0.045 | nM | 10.35 |
| CHEMBL1243285 | — | EC50 | = | 0.048 | nM | 10.32 |
| CHEMBL1243407 | ZINTEROL | EC50 | = | 0.054 | nM | 10.27 |
| CHEMBL1243317 | — | EC50 | = | 0.056 | nM | 10.25 |
| CHEMBL402501 | — | EC50 | = | 0.064 | nM | 10.19 |
| CHEMBL1243347 | — | EC50 | = | 0.066 | nM | 10.18 |
| CHEMBL1263 | SALMETEROL | EC50 | = | 0.07 | nM | 10.15 |
| CHEMBL1243068 | — | EC50 | = | 0.091 | nM | 10.04 |
| CHEMBL1243035 | — | EC50 | = | 0.13 | nM | 9.89 |
| CHEMBL1243000 | — | EC50 | = | 0.17 | nM | 9.77 |
| CHEMBL1240965 | — | EC50 | = | 0.21 | nM | 9.68 |
| CHEMBL1240966 | — | EC50 | = | 0.24 | nM | 9.62 |
| CHEMBL1240967 | PF-00610355 | EC50 | = | 0.26 | nM | 9.59 |
| CHEMBL1242969 | — | EC50 | = | 0.37 | nM | 9.43 |