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Compound Detail

CHEMBL1242969

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CCN(Cc1ccc(O)cc1Cl)C(=O)Cc1cccc(CC(C)(C)NC[C@H](O)c2ccc(O)c(NS(C)(=O)=O)c2)c1

Basic Information

ChEMBL ID CHEMBL1242969
Phase Preclinical
Structure Type MOL
InChI Key CLUFTXJUPWPJGK-NDEPHWFRSA-N
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names

Molecular Properties

604.2
MW (Da)
4.36
ALogP
7
HBA
5
HBD
139.2
PSA (Ų)
0.18
QED
1
Ro5 Violations
13
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C30H38ClN3O6S
MW 604.17
Aromatic Rings 3
Heavy Atoms 41
NP-Likeness -0.86

Activity Summary

EC50 1 meas. best 9.43

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Beta-2 adrenergic receptor
CHEMBL210
EC50 9.43 9.43 0.4 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
20804199 10.1021/jm1005989 NON-PROTEIN TARGET 2
20804199 10.1021/jm1005989 No relevant target 1
20804199 10.1021/jm1005989 Unchecked 1
20804199 10.1021/jm1005989 Beta-2 adrenergic receptor 1

Data from ChEMBL 36 via Core Engine