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Compound Detail

CHEMBL1240966

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CC(C)(Cc1cccc(CC(=O)NCc2ccc(-c3ccc(O)cc3)cc2)c1)NC[C@H](O)c1ccc(O)c(NS(C)(=O)=O)c1

Basic Information

ChEMBL ID CHEMBL1240966
Phase Preclinical
Structure Type MOL
InChI Key YJWDSNSUCGERRI-YTTGMZPUSA-N
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names

Molecular Properties

617.8
MW (Da)
4.64
ALogP
7
HBA
6
HBD
148.0
PSA (Ų)
0.12
QED
2
Ro5 Violations
13
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C34H39N3O6S
MW 617.77
Aromatic Rings 4
Heavy Atoms 44
NP-Likeness -0.55

Activity Summary

EC50 1 meas. best 9.62

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Beta-2 adrenergic receptor
CHEMBL210
EC50 9.62 9.62 0.2 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
20804199 10.1021/jm1005989 NON-PROTEIN TARGET 2
20804199 10.1021/jm1005989 Unchecked 1
20804199 10.1021/jm1005989 Beta-2 adrenergic receptor 1

Data from ChEMBL 36 via Core Engine