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Target Snapshot

CHEMBL4523872 Target Snapshot

Adhesion G-protein coupled receptor F1 · SINGLE PROTEIN · Homo sapiens

439Compounds
7Assays
2Approved Drugs
26.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

Protein identity stays anchored to UniProt Q5T601. Use UniProt Q5T601 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt Q5T601 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Adhesion G-protein coupled receptor F1 as ChEMBL target CHEMBL4523872, mapped to UniProt Q5T601. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Adhesion G-protein coupled receptor F1
SINGLE PROTEIN · Homo sapiens
As of 2026-09-13
ChEMBL target ID
CHEMBL4523872
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
UniProt accession
Q5T601
Adhesion G-protein coupled receptor F1
UniProt accession via ChEMBL component mapping As of 2026-09-13
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Adhesion G-protein coupled receptor F1 is the right protein anchor across sources, using UniProt Q5T601 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelAdhesion G-protein coupled receptor F1
UniProt AccessionQ5T601
Component TypeProtein
Sequence Length910 aa

Adhesion G-protein coupled receptor F1

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as Adhesion G-protein coupled receptor F1, mapped to UniProt Q5T601. Sequence length is 910 aa.

Mapped IDQ5T601
Review nameAdhesion G-protein coupled receptor F1
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

2
Approved
Assay Mix

Activity Type Distribution

IC5018.0
EC508.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL484929 5.69 EC50 2041.85 Preclinical
CHEMBL1707 5.69 EC50 2040.77 Approved
CHEMBL5092226 5.69 IC50 2051.49 Preclinical
CHEMBL1256876 5.58 IC50 2598.51 Preclinical
CHEMBL531742 5.55 IC50 2839.13 Preclinical
CHEMBL4743495 5.49 IC50 3204.21 Preclinical
CHEMBL1263 5.47 IC50 3409.69 Approved
CHEMBL5089005 5.41 IC50 3893.51 Preclinical
CHEMBL5075931 5.39 IC50 4063.51 Preclinical
CHEMBL1474387 5.3 IC50 4996.8 Preclinical
Distribution

pChEMBL Value Distribution

6
5.0
5
5.5
0
6.0
0
6.5
0
7.0
0
7.5
0
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Assay Landscape

Assay Landscape

7
Total Assays
11
Tested Compounds
2
Assay Types
Functional — 5 assays, 11 compounds
BAO Format Assays Compounds Avg pChEMBL
assay format 3 0
cell-based format 2 11 5.5
Binding — 2 assays, 0 compounds
BAO Format Assays Compounds Avg pChEMBL
single protein format 2 0

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine