Assay Detail
Functional
CHEMBL900403
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Agonist activity at human recombinant adrenergic beta-2 receptor expressed in CHO cells assessed as elevation in cAMP levels
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
The discovery of indole-derived long acting beta2-adrenoceptor agonists for the treatment of asthma and COPD.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 18 | 10.00 | 10.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL236039 | — | — | 1 | 10.70 |
| CHEMBL236041 | — | — | 1 | 10.66 |
| CHEMBL430361 | — | — | 1 | 10.51 |
| CHEMBL391006 | — | — | 1 | 10.42 |
| CHEMBL236040 | — | — | 1 | 10.42 |
| CHEMBL391946 | — | — | 1 | 10.31 |
| CHEMBL236251 | — | — | 1 | 10.29 |
| CHEMBL235612 | — | — | 1 | 10.28 |
| CHEMBL237501 | — | — | 1 | 10.24 |
| CHEMBL392056 | — | — | 1 | 10.24 |
| CHEMBL1263 | SALMETEROL | 4.0 | 1 | 10.15 |
| CHEMBL235818 | — | — | 1 | 9.91 |
| CHEMBL394339 | — | — | 1 | 9.79 |
| CHEMBL236042 | — | — | 1 | 9.60 |
| CHEMBL391308 | — | — | 1 | 9.59 |
| CHEMBL238347 | — | — | 1 | 9.16 |
| CHEMBL428027 | — | — | 1 | 9.15 |
| CHEMBL237709 | — | — | 1 | 8.59 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL236039 | — | EC50 | = | 0.02 | nM | 10.70 |
| CHEMBL236041 | — | EC50 | = | 0.022 | nM | 10.66 |
| CHEMBL430361 | — | EC50 | = | 0.031 | nM | 10.51 |
| CHEMBL391006 | — | EC50 | = | 0.038 | nM | 10.42 |
| CHEMBL236040 | — | EC50 | = | 0.038 | nM | 10.42 |
| CHEMBL391946 | — | EC50 | = | 0.049 | nM | 10.31 |
| CHEMBL236251 | — | EC50 | = | 0.051 | nM | 10.29 |
| CHEMBL235612 | — | EC50 | = | 0.053 | nM | 10.28 |
| CHEMBL237501 | — | EC50 | = | 0.058 | nM | 10.24 |
| CHEMBL392056 | — | EC50 | = | 0.058 | nM | 10.24 |
| CHEMBL1263 | SALMETEROL | EC50 | = | 0.07 | nM | 10.15 |
| CHEMBL235818 | — | EC50 | = | 0.122 | nM | 9.91 |
| CHEMBL394339 | — | EC50 | = | 0.164 | nM | 9.79 |
| CHEMBL236042 | — | EC50 | = | 0.254 | nM | 9.60 |
| CHEMBL391308 | — | EC50 | = | 0.258 | nM | 9.59 |
| CHEMBL238347 | — | EC50 | = | 0.687 | nM | 9.16 |
| CHEMBL428027 | — | EC50 | = | 0.706 | nM | 9.15 |
| CHEMBL237709 | — | EC50 | = | 2.55 | nM | 8.59 |