Assay Detail
Functional
CHEMBL1119458
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Agonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 mins
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and structure-activity relationships of long-acting beta2 adrenergic receptor agonists incorporating metabolic inactivation: an antedrug approach.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 18 | 8.82 | 9.90 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1085837 | — | — | 1 | 9.90 |
| CHEMBL446840 | — | — | 1 | 9.80 |
| CHEMBL1085399 | — | — | 1 | 9.60 |
| CHEMBL1263 | SALMETEROL | 4.0 | 1 | 9.60 |
| CHEMBL1084647 | VILANTEROL ACETATE | — | 1 | 9.40 |
| CHEMBL1084648 | — | — | 1 | 9.40 |
| CHEMBL1084891 | — | — | 1 | 9.40 |
| CHEMBL605993 | — | — | 1 | 9.30 |
| CHEMBL1086536 | — | — | 1 | 9.10 |
| CHEMBL1085638 | — | — | 1 | 8.80 |
| CHEMBL1084656 | — | — | 1 | 8.80 |
| CHEMBL1084655 | — | — | 1 | 8.70 |
| CHEMBL1084654 | — | — | 1 | 8.60 |
| CHEMBL1084649 | — | — | 1 | 8.60 |
| CHEMBL1085395 | — | — | 1 | 8.60 |
| CHEMBL1086535 | — | — | 1 | 8.10 |
| CHEMBL434 | ISOPROTERENOL | 4.0 | 1 | 7.40 |
| CHEMBL1083884 | — | — | 1 | 5.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1085837 | — | EC50 | = | 0.1259 | nM | 9.90 |
| CHEMBL446840 | — | EC50 | = | 0.1585 | nM | 9.80 |
| CHEMBL1085399 | — | EC50 | = | 0.2512 | nM | 9.60 |
| CHEMBL1263 | SALMETEROL | EC50 | = | 0.2512 | nM | 9.60 |
| CHEMBL1084647 | VILANTEROL ACETATE | EC50 | = | 0.3981 | nM | 9.40 |
| CHEMBL1084648 | — | EC50 | = | 0.3981 | nM | 9.40 |
| CHEMBL1084891 | — | EC50 | = | 0.3981 | nM | 9.40 |
| CHEMBL605993 | — | EC50 | = | 0.5012 | nM | 9.30 |
| CHEMBL1086536 | — | EC50 | = | 0.7943 | nM | 9.10 |
| CHEMBL1085638 | — | EC50 | = | 1.585 | nM | 8.80 |
| CHEMBL1084656 | — | EC50 | = | 1.585 | nM | 8.80 |
| CHEMBL1084655 | — | EC50 | = | 1.995 | nM | 8.70 |
| CHEMBL1084654 | — | EC50 | = | 2.512 | nM | 8.60 |
| CHEMBL1084649 | — | EC50 | = | 2.512 | nM | 8.60 |
| CHEMBL1085395 | — | EC50 | = | 2.512 | nM | 8.60 |
| CHEMBL1086535 | — | EC50 | = | 7.943 | nM | 8.10 |
| CHEMBL434 | ISOPROTERENOL | EC50 | = | 39.81 | nM | 7.40 |
| CHEMBL1083884 | — | EC50 | = | 2511.89 | nM | 5.60 |