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Compound Detail

CHEMBL1083884

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CC(=O)O.OCCOCCCCCCNC[C@H](O)c1ccc(O)c(CO)c1

Basic Information

ChEMBL ID CHEMBL1083884
Phase Preclinical
Structure Type MOL
InChI Key CVXARJMJYXZVSG-LMOVPXPDSA-N
Parent Compound CHEMBL1198851
Active Moiety CHEMBL1198851
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names

Molecular Properties

327.4
MW (Da)
1.08
ALogP
6
HBA
5
HBD
102.2
PSA (Ų)
0.35
QED
0
Ro5 Violations
13
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C19H33NO7
MW 387.47
Aromatic Rings 1
Heavy Atoms 23
NP-Likeness 0.36

Activity Summary

EC50 2 meas. best 5.6

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Beta-2 adrenergic receptor
CHEMBL210
EC50 5.6 5.6 2511.9 1
Beta-3 adrenergic receptor
CHEMBL246
EC50 4.9 4.9 12589.2 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
20462258 10.1021/jm100326d Beta-2 adrenergic receptor 2
20462258 10.1021/jm100326d Beta-1 adrenergic receptor 1
20462258 10.1021/jm100326d Beta-3 adrenergic receptor 1

Data from ChEMBL 36 via Core Engine