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Compound Detail

CHEMBL1084655

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NS(=O)(=O)c1ccc(COCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)cc1

Basic Information

ChEMBL ID CHEMBL1084655
Phase Preclinical
Structure Type MOL
InChI Key NBGUCSNEMUHHJX-DEOSSOPVSA-N
3
Targets
3
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names

Molecular Properties

496.6
MW (Da)
1.95
ALogP
8
HBA
5
HBD
151.3
PSA (Ų)
0.21
QED
0
Ro5 Violations
17
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C24H36N2O7S
MW 496.63
Aromatic Rings 2
Heavy Atoms 34
NP-Likeness -0.35

Activity Summary

EC50 3 meas. best 8.7

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Beta-2 adrenergic receptor
CHEMBL210
EC50 8.7 8.7 2.0 1
Beta-1 adrenergic receptor
CHEMBL213
EC50 7.0 7.0 100.0 1
Beta-3 adrenergic receptor
CHEMBL246
EC50 6.4 6.4 398.1 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
20462258 10.1021/jm100326d Beta-2 adrenergic receptor 2
20462258 10.1021/jm100326d Beta-1 adrenergic receptor 1
20462258 10.1021/jm100326d Beta-3 adrenergic receptor 1
20462258 10.1021/jm100326d Liver microsomes 1

Data from ChEMBL 36 via Core Engine