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Compound Detail

CHEMBL1085399

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CC(=O)O.CS(=O)(=O)Nc1cccc(COCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1

Basic Information

ChEMBL ID CHEMBL1085399
Phase Preclinical
Structure Type MOL
InChI Key KVEWFLGJDBNYAW-UQIIZPHYSA-N
Parent Compound CHEMBL1198908
Active Moiety CHEMBL1198908
3
Targets
3
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names

Molecular Properties

510.6
MW (Da)
2.67
ALogP
8
HBA
5
HBD
137.3
PSA (Ų)
0.19
QED
1
Ro5 Violations
18
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C27H42N2O9S
MW 570.71
Aromatic Rings 2
Heavy Atoms 35
NP-Likeness -0.43

Activity Summary

EC50 3 meas. best 9.6

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Beta-2 adrenergic receptor
CHEMBL210
EC50 9.6 9.6 0.3 1
Beta-1 adrenergic receptor
CHEMBL213
EC50 7.9 7.9 12.6 1
Beta-3 adrenergic receptor
CHEMBL246
EC50 7.1 7.1 79.4 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
20462258 10.1021/jm100326d Beta-2 adrenergic receptor 2
20462258 10.1021/jm100326d Beta-1 adrenergic receptor 1
20462258 10.1021/jm100326d Beta-3 adrenergic receptor 1
20462258 10.1021/jm100326d Liver microsomes 1

Data from ChEMBL 36 via Core Engine