Assay Detail
Functional
CHEMBL1816608
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Agonist activity at human adrenergic beta2 receptor expressed in CHO cells assessed as cAMP accumulation
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
The discovery of long-acting saligenin β₂ adrenergic receptor agonists incorporating hydantoin or uracil rings.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 15 | 8.95 | 9.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1814276 | — | — | 1 | 9.60 |
| CHEMBL1263 | SALMETEROL | 4.0 | 1 | 9.60 |
| CHEMBL1256786 | FORMOTEROL | 4.0 | 1 | 9.30 |
| CHEMBL1814268 | — | — | 1 | 9.20 |
| CHEMBL1814274 | — | — | 1 | 9.20 |
| CHEMBL1814271 | — | — | 1 | 9.10 |
| CHEMBL1814275 | — | — | 1 | 9.10 |
| CHEMBL1814277 | — | — | 1 | 9.10 |
| CHEMBL1814279 | — | — | 1 | 9.00 |
| CHEMBL1814273 | — | — | 1 | 8.90 |
| CHEMBL1814267 | — | — | 1 | 8.90 |
| CHEMBL1814269 | — | — | 1 | 8.70 |
| CHEMBL1814270 | — | — | 1 | 8.60 |
| CHEMBL1814272 | — | — | 1 | 8.60 |
| CHEMBL434 | ISOPROTERENOL | 4.0 | 1 | 7.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1814276 | — | EC50 | = | 0.2512 | nM | 9.60 |
| CHEMBL1263 | SALMETEROL | EC50 | = | 0.2512 | nM | 9.60 |
| CHEMBL1256786 | FORMOTEROL | EC50 | = | 0.5012 | nM | 9.30 |
| CHEMBL1814268 | — | EC50 | = | 0.631 | nM | 9.20 |
| CHEMBL1814274 | — | EC50 | = | 0.631 | nM | 9.20 |
| CHEMBL1814271 | — | EC50 | = | 0.7943 | nM | 9.10 |
| CHEMBL1814275 | — | EC50 | = | 0.7943 | nM | 9.10 |
| CHEMBL1814277 | — | EC50 | = | 0.7943 | nM | 9.10 |
| CHEMBL1814279 | — | EC50 | = | 1.0 | nM | 9.00 |
| CHEMBL1814273 | — | EC50 | = | 1.259 | nM | 8.90 |
| CHEMBL1814267 | — | EC50 | = | 1.259 | nM | 8.90 |
| CHEMBL1814269 | — | EC50 | = | 1.995 | nM | 8.70 |
| CHEMBL1814270 | — | EC50 | = | 2.512 | nM | 8.60 |
| CHEMBL1814272 | — | EC50 | = | 2.512 | nM | 8.60 |
| CHEMBL434 | ISOPROTERENOL | EC50 | = | 39.81 | nM | 7.40 |