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Compound Detail

CHEMBL1814267

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CC(=O)O.O=c1ccn(-c2cccc(CCCCOCCCCCCNC[C@H](O)c3ccc(O)c(CO)c3)c2)c(=O)[nH]1

Basic Information

ChEMBL ID CHEMBL1814267
Phase Preclinical
Structure Type MOL
InChI Key RJDWAMSJHJOIQV-YCBFMBTMSA-N
Parent Compound CHEMBL1851721
Active Moiety CHEMBL1851721
3
Targets
3
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names

Molecular Properties

525.6
MW (Da)
2.95
ALogP
8
HBA
5
HBD
136.8
PSA (Ų)
0.17
QED
1
Ro5 Violations
17
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C31H43N3O8
MW 585.70
Aromatic Rings 3
Heavy Atoms 38
NP-Likeness -0.14

Activity Summary

EC50 3 meas. best 8.9

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Beta-2 adrenergic receptor
CHEMBL210
EC50 8.9 8.9 1.3 1
Beta-1 adrenergic receptor
CHEMBL213
EC50 7.3 7.3 50.1 1
Beta-3 adrenergic receptor
CHEMBL246
EC50 7.3 7.3 50.1 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
21696967 10.1016/j.bmc.2011.05.064 Beta-2 adrenergic receptor 2
21696967 10.1016/j.bmc.2011.05.064 Beta-1 adrenergic receptor 1
21696967 10.1016/j.bmc.2011.05.064 Beta-3 adrenergic receptor 1
21696967 10.1016/j.bmc.2011.05.064 Liver microsomes 1

Data from ChEMBL 36 via Core Engine