Assay Detail
Functional
CHEMBL1816605
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Agonist activity at human adrenergic beta3 receptor expressed in CHO cells assessed as cAMP accumulation
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
The discovery of long-acting saligenin β₂ adrenergic receptor agonists incorporating hydantoin or uracil rings.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 15 | 7.05 | 7.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1814275 | — | — | 1 | 7.60 |
| CHEMBL1256786 | FORMOTEROL | 4.0 | 1 | 7.60 |
| CHEMBL1814269 | — | — | 1 | 7.50 |
| CHEMBL1814273 | — | — | 1 | 7.40 |
| CHEMBL434 | ISOPROTERENOL | 4.0 | 1 | 7.40 |
| CHEMBL1814267 | — | — | 1 | 7.30 |
| CHEMBL1814271 | — | — | 1 | 7.20 |
| CHEMBL1814274 | — | — | 1 | 7.20 |
| CHEMBL1814276 | — | — | 1 | 7.10 |
| CHEMBL1814268 | — | — | 1 | 7.00 |
| CHEMBL1814279 | — | — | 1 | 7.00 |
| CHEMBL1814270 | — | — | 1 | 6.70 |
| CHEMBL1814272 | — | — | 1 | 6.50 |
| CHEMBL1814277 | — | — | 1 | 6.40 |
| CHEMBL1263 | SALMETEROL | 4.0 | 1 | 5.90 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1814275 | — | EC50 | = | 25.12 | nM | 7.60 |
| CHEMBL1256786 | FORMOTEROL | EC50 | = | 25.12 | nM | 7.60 |
| CHEMBL1814269 | — | EC50 | = | 31.62 | nM | 7.50 |
| CHEMBL1814273 | — | EC50 | = | 39.81 | nM | 7.40 |
| CHEMBL434 | ISOPROTERENOL | EC50 | = | 39.81 | nM | 7.40 |
| CHEMBL1814267 | — | EC50 | = | 50.12 | nM | 7.30 |
| CHEMBL1814271 | — | EC50 | = | 63.1 | nM | 7.20 |
| CHEMBL1814274 | — | EC50 | = | 63.1 | nM | 7.20 |
| CHEMBL1814276 | — | EC50 | = | 79.43 | nM | 7.10 |
| CHEMBL1814268 | — | EC50 | = | 100.0 | nM | 7.00 |
| CHEMBL1814279 | — | EC50 | = | 100.0 | nM | 7.00 |
| CHEMBL1814270 | — | EC50 | = | 199.53 | nM | 6.70 |
| CHEMBL1814272 | — | EC50 | = | 316.23 | nM | 6.50 |
| CHEMBL1814277 | — | EC50 | = | 398.11 | nM | 6.40 |
| CHEMBL1263 | SALMETEROL | EC50 | = | 1258.93 | nM | 5.90 |